Low-Dose Endotoxin Induces Late Preconditioning, Increases Peroxynitrite Formation, and Activates STAT3 in the Rat Heart

Low-Dose Endotoxin Induces Late Preconditioning, Increases Peroxynitrite Formation, and Activates STAT3 in the Rat Heart

Administration of low-dose endotoxin (lipopolysaccharide, LPS) 24 h before a lethal ischemia induces pharmacological late preconditioning. The exact mechanism of this phenomenon is not clear. Here we aimed to investigate whether low-dose LPS exerts late effects on peroxynitrite formation and activat...

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Bibliographic Details
Main Authors: Márton Pipicz, Gabriella F. Kocsis, László Sárváry-Arantes, Péter Bencsik, Zoltán V. Varga, Péter Ferdinandy, Tamás Csont
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Molecules
Subjects:
oxidative stress
ONOO−
iNOS
XOR
SAFE pathway
cardioprotection
Online Access:http://www.mdpi.com/1420-3049/22/3/433

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