Effect of genetic background and delivery route on the preclinical properties of a live attenuated RSV vaccine.

Effect of genetic background and delivery route on the preclinical properties of a live attenuated RSV vaccine.

A safe and effective vaccine against RSV remains an important unmet public health need. Intranasally (IN) delivered live-attenuated vaccines represent the most extensively studied approach for immunization of RSV-naïve infants and children, however, achieving an effective balance of attenuation and...

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Bibliographic Details
Main Authors: Rachel Groppo, Joshua DiNapoli, Kwang Il Jeong, Michael Kishko, Nicholas Jackson, Harold Kleanthous, Simon Delagrave, Linong Zhang, Mark Parrington
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6007926?pdf=render

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