Research trend of microbiota-gut-brain axis in Alzheimer’s disease based on CiteSpace (2012–2021): A bibliometrics analysis of 608 articles
BackgroundRecently, research on the microbiota-gut-brain axis (MGBA) has received increasing attention, and the number of studies related to Alzheimer’s disease (AD) has increased rapidly, but there is currently a lack of summary of MGBA in AD.ObjectiveTo capture research hotspots, grasp the context...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1036120/full |
| _version_ | 1811189103017852928 |
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| author | Zi-Long Li Zi-Long Li Hao-Tian Ma Meng Wang Meng Wang Yi-Hua Qian Yi-Hua Qian |
| author_facet | Zi-Long Li Zi-Long Li Hao-Tian Ma Meng Wang Meng Wang Yi-Hua Qian Yi-Hua Qian |
| author_sort | Zi-Long Li |
| collection | DOAJ |
| description | BackgroundRecently, research on the microbiota-gut-brain axis (MGBA) has received increasing attention, and the number of studies related to Alzheimer’s disease (AD) has increased rapidly, but there is currently a lack of summary of MGBA in AD.ObjectiveTo capture research hotspots, grasp the context of disciplinary research, and explore future research development directions.MethodsIn the core dataset of Web of Science, documents are searched according to specific subject words. CiteSpace software is used to perform statistical analysis on measurement indicators such as the number of published papers, publishing countries, institutions, subject areas, authors, cocited journals, and keywords, and to visualize of a network of relevant content elements.ResultsThe research of MGBA in AD has shown an upward trend year by year, and the cooperation between countries is relatively close, and mainly involves the intersection of neuroscience, pharmacy, and microbiology. This research focuses on the relationship between MGBA and AD symptoms. Keyword hotspots are closely related to new technologies. Alzheimer’s disease, anterior cingulate cortex, inflammatory degeneration, dysbiosis, and other research are the focus of this field.ConclusionThe study revealed that the research and development of MGBA in AD rapidly progressed, but no breakthrough has been made in the past decade, it still needs to be closely combined with multidisciplinary technology to grasp the frontier hotspots. Countries should further strengthen cooperation, improve the disciplinary system, and increase the proportion of empirical research in all research. |
| first_indexed | 2024-04-11T14:30:18Z |
| format | Article |
| id | doaj.art-c50c6127a6c54ff59ee31c1a445ff8c9 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-11T14:30:18Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-c50c6127a6c54ff59ee31c1a445ff8c92022-12-22T04:18:40ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-11-011410.3389/fnagi.2022.10361201036120Research trend of microbiota-gut-brain axis in Alzheimer’s disease based on CiteSpace (2012–2021): A bibliometrics analysis of 608 articlesZi-Long Li0Zi-Long Li1Hao-Tian Ma2Meng Wang3Meng Wang4Yi-Hua Qian5Yi-Hua Qian6Department of Human Anatomy and Histoembryology, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaInstitute of Neuroscience, Translational Medicine Institute, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, ChinaCollege of Forensic Science, Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Human Anatomy and Histoembryology, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaInstitute of Neuroscience, Translational Medicine Institute, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, ChinaDepartment of Human Anatomy and Histoembryology, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaInstitute of Neuroscience, Translational Medicine Institute, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, ChinaBackgroundRecently, research on the microbiota-gut-brain axis (MGBA) has received increasing attention, and the number of studies related to Alzheimer’s disease (AD) has increased rapidly, but there is currently a lack of summary of MGBA in AD.ObjectiveTo capture research hotspots, grasp the context of disciplinary research, and explore future research development directions.MethodsIn the core dataset of Web of Science, documents are searched according to specific subject words. CiteSpace software is used to perform statistical analysis on measurement indicators such as the number of published papers, publishing countries, institutions, subject areas, authors, cocited journals, and keywords, and to visualize of a network of relevant content elements.ResultsThe research of MGBA in AD has shown an upward trend year by year, and the cooperation between countries is relatively close, and mainly involves the intersection of neuroscience, pharmacy, and microbiology. This research focuses on the relationship between MGBA and AD symptoms. Keyword hotspots are closely related to new technologies. Alzheimer’s disease, anterior cingulate cortex, inflammatory degeneration, dysbiosis, and other research are the focus of this field.ConclusionThe study revealed that the research and development of MGBA in AD rapidly progressed, but no breakthrough has been made in the past decade, it still needs to be closely combined with multidisciplinary technology to grasp the frontier hotspots. Countries should further strengthen cooperation, improve the disciplinary system, and increase the proportion of empirical research in all research.https://www.frontiersin.org/articles/10.3389/fnagi.2022.1036120/fullmicrobiota-gut-brain axismicrobiotaAlzheimer’s diseaseresearch trendsbibliometric analysisWeb of Science database |
| spellingShingle | Zi-Long Li Zi-Long Li Hao-Tian Ma Meng Wang Meng Wang Yi-Hua Qian Yi-Hua Qian Research trend of microbiota-gut-brain axis in Alzheimer’s disease based on CiteSpace (2012–2021): A bibliometrics analysis of 608 articles Frontiers in Aging Neuroscience microbiota-gut-brain axis microbiota Alzheimer’s disease research trends bibliometric analysis Web of Science database |
| title | Research trend of microbiota-gut-brain axis in Alzheimer’s disease based on CiteSpace (2012–2021): A bibliometrics analysis of 608 articles |
| title_full | Research trend of microbiota-gut-brain axis in Alzheimer’s disease based on CiteSpace (2012–2021): A bibliometrics analysis of 608 articles |
| title_fullStr | Research trend of microbiota-gut-brain axis in Alzheimer’s disease based on CiteSpace (2012–2021): A bibliometrics analysis of 608 articles |
| title_full_unstemmed | Research trend of microbiota-gut-brain axis in Alzheimer’s disease based on CiteSpace (2012–2021): A bibliometrics analysis of 608 articles |
| title_short | Research trend of microbiota-gut-brain axis in Alzheimer’s disease based on CiteSpace (2012–2021): A bibliometrics analysis of 608 articles |
| title_sort | research trend of microbiota gut brain axis in alzheimer s disease based on citespace 2012 2021 a bibliometrics analysis of 608 articles |
| topic | microbiota-gut-brain axis microbiota Alzheimer’s disease research trends bibliometric analysis Web of Science database |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1036120/full |
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