Type I interferon response in astrocytes promotes brain metastasis by enhancing monocytic myeloid cell recruitment

Abstract Cancer metastasis to the brain is a significant clinical problem. Metastasis is the consequence of favorable interactions between invaded cancer cells and the microenvironment. Here, we demonstrate that cancer-activated astrocytes create a sustained low-level activated type I interferon (IF...

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Bibliographic Details
Main Authors: Weili Ma, Maria Cecília Oliveira-Nunes, Ke Xu, Andrew Kossenkov, Benjamin C. Reiner, Richard C. Crist, James Hayden, Qing Chen
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38252-8

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