Histopathological differentiation between well differentiated oral squamous cell carcinoma and oral verrucous carcinoma with special staining of basement membrane
Background and Aim: Microscopic differentiation between well differentiated squamous cell carcinoma and verrucous carcinoma is very difficult. As these lesions have different clinical course and treatment a reliable method to help distinguish between them is necessary. The basement membrane in oral...
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| Format: | Article |
| Language: | fas |
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Tehran University of Medical Sciences
2007-01-01
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| Series: | Journal of Dental Medicine |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3072.pdf&manuscript_id=3072 |
| _version_ | 1811318087230685184 |
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| author | Ashoori M Salimian A Jalayer Naderi N |
| author_facet | Ashoori M Salimian A Jalayer Naderi N |
| author_sort | Ashoori M |
| collection | DOAJ |
| description | Background and Aim: Microscopic differentiation between well differentiated squamous cell carcinoma and verrucous carcinoma is very difficult. As these lesions have different clinical course and treatment a reliable method to help distinguish between them is necessary. The basement membrane in oral verrucous carcinoma is generally intact whereas in oral squamous cell carcinoma is mostly discontinuous. This structure can be studied by different methods. The aim of this study was to differentiate these lesions with special staining of basement membrane. Materials and Methods: In this tests evaluation study, a total of 26 cases consisting of 15 oral squamous cell carcinomas and 11 oral verrucous carcinomas were retrieved from Cancer Institute of Imam Khomeini hospital archive of pathology and their paraffin blocks were cut and stained with Periodic Acid Schiff method. Slides were studied with light microscope to evaluate the continuity of basement membrane. Sensitivity and specificity of this method were calculated. Results: The sensitivity of this method for differentiating oral squamous cell carcinoma from oral verrucous carcinoma was 100% whereas the specificity was 90.9%. Positive predictive value was 93.75% and negative predictive value 100%. Conclusion: Based on the results of this study, the sensitivity of this test for diagnosis of oral squamous cell carcinoma was high (100%). Further studies are needed to evaluate the use this method for distinguishing oral verrucous carcinoma from oral squamous cell carcinoma. |
| first_indexed | 2024-04-13T12:19:45Z |
| format | Article |
| id | doaj.art-c50de1f3946949138d21cf862e5306a2 |
| institution | Directory Open Access Journal |
| issn | 1024-641X 2008-2444 |
| language | fas |
| last_indexed | 2024-04-13T12:19:45Z |
| publishDate | 2007-01-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Journal of Dental Medicine |
| spelling | doaj.art-c50de1f3946949138d21cf862e5306a22022-12-22T02:47:15ZfasTehran University of Medical SciencesJournal of Dental Medicine1024-641X2008-24442007-01-011948994Histopathological differentiation between well differentiated oral squamous cell carcinoma and oral verrucous carcinoma with special staining of basement membraneAshoori MSalimian AJalayer Naderi NBackground and Aim: Microscopic differentiation between well differentiated squamous cell carcinoma and verrucous carcinoma is very difficult. As these lesions have different clinical course and treatment a reliable method to help distinguish between them is necessary. The basement membrane in oral verrucous carcinoma is generally intact whereas in oral squamous cell carcinoma is mostly discontinuous. This structure can be studied by different methods. The aim of this study was to differentiate these lesions with special staining of basement membrane. Materials and Methods: In this tests evaluation study, a total of 26 cases consisting of 15 oral squamous cell carcinomas and 11 oral verrucous carcinomas were retrieved from Cancer Institute of Imam Khomeini hospital archive of pathology and their paraffin blocks were cut and stained with Periodic Acid Schiff method. Slides were studied with light microscope to evaluate the continuity of basement membrane. Sensitivity and specificity of this method were calculated. Results: The sensitivity of this method for differentiating oral squamous cell carcinoma from oral verrucous carcinoma was 100% whereas the specificity was 90.9%. Positive predictive value was 93.75% and negative predictive value 100%. Conclusion: Based on the results of this study, the sensitivity of this test for diagnosis of oral squamous cell carcinoma was high (100%). Further studies are needed to evaluate the use this method for distinguishing oral verrucous carcinoma from oral squamous cell carcinoma.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3072.pdf&manuscript_id=3072Oral verrucous carcinomaBasement membranePeriodic acid schiff techniqueHistopathologic differentiation |
| spellingShingle | Ashoori M Salimian A Jalayer Naderi N Histopathological differentiation between well differentiated oral squamous cell carcinoma and oral verrucous carcinoma with special staining of basement membrane Journal of Dental Medicine Oral verrucous carcinoma Basement membrane Periodic acid schiff technique Histopathologic differentiation |
| title | Histopathological differentiation between well differentiated oral squamous cell carcinoma and oral verrucous carcinoma with special staining of basement membrane |
| title_full | Histopathological differentiation between well differentiated oral squamous cell carcinoma and oral verrucous carcinoma with special staining of basement membrane |
| title_fullStr | Histopathological differentiation between well differentiated oral squamous cell carcinoma and oral verrucous carcinoma with special staining of basement membrane |
| title_full_unstemmed | Histopathological differentiation between well differentiated oral squamous cell carcinoma and oral verrucous carcinoma with special staining of basement membrane |
| title_short | Histopathological differentiation between well differentiated oral squamous cell carcinoma and oral verrucous carcinoma with special staining of basement membrane |
| title_sort | histopathological differentiation between well differentiated oral squamous cell carcinoma and oral verrucous carcinoma with special staining of basement membrane |
| topic | Oral verrucous carcinoma Basement membrane Periodic acid schiff technique Histopathologic differentiation |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3072.pdf&manuscript_id=3072 |
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