Prime Editor 3 Mediated Beta-Thalassemia Mutations of the <i>HBB</i> Gene in Human Erythroid Progenitor Cells

Prime Editor 3 Mediated Beta-Thalassemia Mutations of the <i>HBB</i> Gene in Human Erythroid Progenitor Cells

Recently developed Prime Editor 3 (PE3) has been implemented to induce genome editing in various cell types but has not been proven in human hematopoietic stem and progenitor cells. Using PE3, we successfully installed the beta-thalassemia (beta-thal) mutations in the HBB gene in the erythroid proge...

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Bibliographic Details
Main Authors: Haokun Zhang, Qinlinglan Zhou, Hongyan Chen, Daru Lu
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
prime editor 3
beta-thalassemia mutation
the <i>HBB</i> gene
HUDEP-2 cells
genome editing
Online Access:https://www.mdpi.com/1422-0067/23/9/5002

Internet

https://www.mdpi.com/1422-0067/23/9/5002

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