Prime Editor 3 Mediated Beta-Thalassemia Mutations of the <i>HBB</i> Gene in Human Erythroid Progenitor Cells
Recently developed Prime Editor 3 (PE3) has been implemented to induce genome editing in various cell types but has not been proven in human hematopoietic stem and progenitor cells. Using PE3, we successfully installed the beta-thalassemia (beta-thal) mutations in the HBB gene in the erythroid proge...
Main Authors: | Haokun Zhang, Qinlinglan Zhou, Hongyan Chen, Daru Lu |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-04-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/23/9/5002 |
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