<i>bla</i><sub>NDM</sub> and <i>mcr-1</i> to <i>mcr-5</i> Gene Distribution Characteristics in Gut Specimens from Different Regions of China
Antibiotic resistance has become a global public health concern. To determine the distribution characteristics of <i>mcr</i> and <i>bla</i><sub>NDM</sub> in China, gene screening was conducted directly from gut specimens sourced from livestock and poultry, poultry...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/3/233 |
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| author | Dongyue Lv Ran Duan Rong Fan Hui Mu Junrong Liang Meng Xiao Zhaokai He Shuai Qin Jinchuan Yang Huaiqi Jing Zhaoguo Wang Xin Wang |
| author_facet | Dongyue Lv Ran Duan Rong Fan Hui Mu Junrong Liang Meng Xiao Zhaokai He Shuai Qin Jinchuan Yang Huaiqi Jing Zhaoguo Wang Xin Wang |
| author_sort | Dongyue Lv |
| collection | DOAJ |
| description | Antibiotic resistance has become a global public health concern. To determine the distribution characteristics of <i>mcr</i> and <i>bla</i><sub>NDM</sub> in China, gene screening was conducted directly from gut specimens sourced from livestock and poultry, poultry environments, human diarrhea patients, and wild animals from 10 regions, between 2010–2020. The positive rate was 5.09% (356/6991) for <i>mcr</i> and 0.41% (29/6991) for <i>bla</i><sub>NDM</sub>, as detected in gut specimens from seven regions, throughout 2010 to 2019, but not detected in 2020. The detection rate of <i>mcr</i> showed significant differences among various sources: livestock and poultry (14.81%) > diarrhea patients (1.43%) > wild animals (0.36%). The detection rate of <i>bla</i><sub>NDM</sub> was also higher in livestock and poultry (0.88%) than in diarrhea patients (0.17%), and this was undetected in wildlife. This is consistent with the relatively high detection rate of multiple <i>mcr</i> genotypes in livestock and poultry. All instances of coexistence of the <i>mcr-1</i> and <i>bla</i><sub>NDM</sub> genes, as well as coexistence of <i>mcr</i> genotypes within single specimens, and most new <i>mcr</i> subtypes came from livestock, and poultry environments. Our study indicates that the emergence of <i>mcr</i> and <i>bla</i><sub>NDM</sub> genes in China is closely related to the selective pressure of carbapenem and polymyxin. The gene-based strategy is proposed to identify more resistance genes of concern, possibly providing guidance for the prevention and control of antimicrobial resistance dissemination. |
| first_indexed | 2024-03-09T00:31:48Z |
| format | Article |
| id | doaj.art-c50f8900ad0f4cfb9f00fe0f19c8e744 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T00:31:48Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-c50f8900ad0f4cfb9f00fe0f19c8e7442023-12-11T18:27:09ZengMDPI AGAntibiotics2079-63822021-02-0110323310.3390/antibiotics10030233<i>bla</i><sub>NDM</sub> and <i>mcr-1</i> to <i>mcr-5</i> Gene Distribution Characteristics in Gut Specimens from Different Regions of ChinaDongyue Lv0Ran Duan1Rong Fan2Hui Mu3Junrong Liang4Meng Xiao5Zhaokai He6Shuai Qin7Jinchuan Yang8Huaiqi Jing9Zhaoguo Wang10Xin Wang11Department of Epidemiology and Health Statistics, The School of Public Health of Qingdao University, Qingdao 266021, ChinaState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaDepartment of Epidemiology and Health Statistics, The School of Public Health of Qingdao University, Qingdao 266021, ChinaState Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, ChinaAntibiotic resistance has become a global public health concern. To determine the distribution characteristics of <i>mcr</i> and <i>bla</i><sub>NDM</sub> in China, gene screening was conducted directly from gut specimens sourced from livestock and poultry, poultry environments, human diarrhea patients, and wild animals from 10 regions, between 2010–2020. The positive rate was 5.09% (356/6991) for <i>mcr</i> and 0.41% (29/6991) for <i>bla</i><sub>NDM</sub>, as detected in gut specimens from seven regions, throughout 2010 to 2019, but not detected in 2020. The detection rate of <i>mcr</i> showed significant differences among various sources: livestock and poultry (14.81%) > diarrhea patients (1.43%) > wild animals (0.36%). The detection rate of <i>bla</i><sub>NDM</sub> was also higher in livestock and poultry (0.88%) than in diarrhea patients (0.17%), and this was undetected in wildlife. This is consistent with the relatively high detection rate of multiple <i>mcr</i> genotypes in livestock and poultry. All instances of coexistence of the <i>mcr-1</i> and <i>bla</i><sub>NDM</sub> genes, as well as coexistence of <i>mcr</i> genotypes within single specimens, and most new <i>mcr</i> subtypes came from livestock, and poultry environments. Our study indicates that the emergence of <i>mcr</i> and <i>bla</i><sub>NDM</sub> genes in China is closely related to the selective pressure of carbapenem and polymyxin. The gene-based strategy is proposed to identify more resistance genes of concern, possibly providing guidance for the prevention and control of antimicrobial resistance dissemination.https://www.mdpi.com/2079-6382/10/3/233<i>bla</i> <sub>NDM</sub><i>mcr</i>carbapenempolymyxin |
| spellingShingle | Dongyue Lv Ran Duan Rong Fan Hui Mu Junrong Liang Meng Xiao Zhaokai He Shuai Qin Jinchuan Yang Huaiqi Jing Zhaoguo Wang Xin Wang <i>bla</i><sub>NDM</sub> and <i>mcr-1</i> to <i>mcr-5</i> Gene Distribution Characteristics in Gut Specimens from Different Regions of China Antibiotics <i>bla</i> <sub>NDM</sub> <i>mcr</i> carbapenem polymyxin |
| title | <i>bla</i><sub>NDM</sub> and <i>mcr-1</i> to <i>mcr-5</i> Gene Distribution Characteristics in Gut Specimens from Different Regions of China |
| title_full | <i>bla</i><sub>NDM</sub> and <i>mcr-1</i> to <i>mcr-5</i> Gene Distribution Characteristics in Gut Specimens from Different Regions of China |
| title_fullStr | <i>bla</i><sub>NDM</sub> and <i>mcr-1</i> to <i>mcr-5</i> Gene Distribution Characteristics in Gut Specimens from Different Regions of China |
| title_full_unstemmed | <i>bla</i><sub>NDM</sub> and <i>mcr-1</i> to <i>mcr-5</i> Gene Distribution Characteristics in Gut Specimens from Different Regions of China |
| title_short | <i>bla</i><sub>NDM</sub> and <i>mcr-1</i> to <i>mcr-5</i> Gene Distribution Characteristics in Gut Specimens from Different Regions of China |
| title_sort | i bla i sub ndm sub and i mcr 1 i to i mcr 5 i gene distribution characteristics in gut specimens from different regions of china |
| topic | <i>bla</i> <sub>NDM</sub> <i>mcr</i> carbapenem polymyxin |
| url | https://www.mdpi.com/2079-6382/10/3/233 |
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