Impact of the ABCB1 Drug Resistance Gene on the Risk Factors of Patients with COVID-19 and Its Relationship with the Drugs Used
Irma Olarte Carrillo,1 Christian Omar Ramos Peñafiel,2 Iveth Mendoza Salas,2 Rafael Cerón Maldonado,1 Anel Irais García Laguna,1 Adrián De la Cruz Rosas,1 Carlos Martinez Murrillo,2 Adolfo Martinez Tovar1 1Laboratorio de Biología Molecular, Servicio de Hematología, Hospital General de México, “Dr. E...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2022-05-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/impact-of-the-abcb1-drug-resistance-gene-on-the-risk-factors-of-patien-peer-reviewed-fulltext-article-IDR |
| _version_ | 1818550925484097536 |
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| author | Olarte Carrillo I Ramos Peñafiel CO Mendoza Salas I Cerón Maldonado R García Laguna AI De la Cruz Rosas A Martinez Murrillo C Martinez Tovar A |
| author_facet | Olarte Carrillo I Ramos Peñafiel CO Mendoza Salas I Cerón Maldonado R García Laguna AI De la Cruz Rosas A Martinez Murrillo C Martinez Tovar A |
| author_sort | Olarte Carrillo I |
| collection | DOAJ |
| description | Irma Olarte Carrillo,1 Christian Omar Ramos Peñafiel,2 Iveth Mendoza Salas,2 Rafael Cerón Maldonado,1 Anel Irais García Laguna,1 Adrián De la Cruz Rosas,1 Carlos Martinez Murrillo,2 Adolfo Martinez Tovar1 1Laboratorio de Biología Molecular, Servicio de Hematología, Hospital General de México, “Dr. Eduardo Liceaga”, Ciudad de México, Mexico; 2Servicio de Hematología, Hospital General de México, “Dr. Eduardo Liceaga”, Ciudad de México, MexicoCorrespondence: Adolfo Martinez Tovar, Labortororio de Biología Molecular, Servicio de Hematología, Hospital General de Mexico “Dr. Eduardo Liceaga”, Ciudad de México, Mexico, Email mtadolfo73@hotmail.comObjective: In the last two years progress was made in molecular, physio pathological understanding and the form of transmission of COVID-19, and different therapeutic strategies have been explored to deal with the situation of the pandemic. However, the evaluation of certain genes that participate in the metabolism and transport of these drugs has not been fully explored. A lack of response to treatment and a lower survival have been observed that may be due to the presence of the ABCB1 drug resistance gene. Our research group analyzed whether the expression levels of the ABCB1 gene are associated with comorbidities, treatments, overall survival and risk of death in patients with severe COVID-19.Methods: The expression levels of the ABCB1 gene were analyzed by RT-qPCR in 61 patients diagnosed with COVID-19. The association between the levels of expression, the risk variables and different treatments were determined by the Chi-Square test and the Fisher’s exact test. Global Survival (GS) was determined by the Kaplan–Meier method. The impact of high levels of expression and the risk of death was performed by odds ratio.Results: The different risk variables showed that patients with either high or absent levels of ABCB1 gene expression presented a greater risk of death (OR 3.08, 95%, CI 1.02– 9.26) as well as need for ventilatory support (OR 2.8, 95%, CI 0.98 − 8.5). Patients with diabetes and COVID-19, treated with metformin, were associated with a lower risk of death (OR 1.11, 95%, CI 0.38– 3.22). OS with respect to high or absent levels of expression of the ABCB1 gene was lower.Conclusion: High levels or null expression of the ABCB1 gene are associated with a higher risk of death or progression of the disease, the use of metformin in patients with COVID-19 confers a lower risk of death.Keywords: ABCB1, SARS-CoV2, drug transporter genes |
| first_indexed | 2024-12-12T08:53:02Z |
| format | Article |
| id | doaj.art-c5115d44fe02429ab6ed23eda4240c10 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-12T08:53:02Z |
| publishDate | 2022-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-c5115d44fe02429ab6ed23eda4240c102022-12-22T00:30:07ZengDove Medical PressInfection and Drug Resistance1178-69732022-05-01Volume 152661266975498Impact of the ABCB1 Drug Resistance Gene on the Risk Factors of Patients with COVID-19 and Its Relationship with the Drugs UsedOlarte Carrillo IRamos Peñafiel COMendoza Salas ICerón Maldonado RGarcía Laguna AIDe la Cruz Rosas AMartinez Murrillo CMartinez Tovar AIrma Olarte Carrillo,1 Christian Omar Ramos Peñafiel,2 Iveth Mendoza Salas,2 Rafael Cerón Maldonado,1 Anel Irais García Laguna,1 Adrián De la Cruz Rosas,1 Carlos Martinez Murrillo,2 Adolfo Martinez Tovar1 1Laboratorio de Biología Molecular, Servicio de Hematología, Hospital General de México, “Dr. Eduardo Liceaga”, Ciudad de México, Mexico; 2Servicio de Hematología, Hospital General de México, “Dr. Eduardo Liceaga”, Ciudad de México, MexicoCorrespondence: Adolfo Martinez Tovar, Labortororio de Biología Molecular, Servicio de Hematología, Hospital General de Mexico “Dr. Eduardo Liceaga”, Ciudad de México, Mexico, Email mtadolfo73@hotmail.comObjective: In the last two years progress was made in molecular, physio pathological understanding and the form of transmission of COVID-19, and different therapeutic strategies have been explored to deal with the situation of the pandemic. However, the evaluation of certain genes that participate in the metabolism and transport of these drugs has not been fully explored. A lack of response to treatment and a lower survival have been observed that may be due to the presence of the ABCB1 drug resistance gene. Our research group analyzed whether the expression levels of the ABCB1 gene are associated with comorbidities, treatments, overall survival and risk of death in patients with severe COVID-19.Methods: The expression levels of the ABCB1 gene were analyzed by RT-qPCR in 61 patients diagnosed with COVID-19. The association between the levels of expression, the risk variables and different treatments were determined by the Chi-Square test and the Fisher’s exact test. Global Survival (GS) was determined by the Kaplan–Meier method. The impact of high levels of expression and the risk of death was performed by odds ratio.Results: The different risk variables showed that patients with either high or absent levels of ABCB1 gene expression presented a greater risk of death (OR 3.08, 95%, CI 1.02– 9.26) as well as need for ventilatory support (OR 2.8, 95%, CI 0.98 − 8.5). Patients with diabetes and COVID-19, treated with metformin, were associated with a lower risk of death (OR 1.11, 95%, CI 0.38– 3.22). OS with respect to high or absent levels of expression of the ABCB1 gene was lower.Conclusion: High levels or null expression of the ABCB1 gene are associated with a higher risk of death or progression of the disease, the use of metformin in patients with COVID-19 confers a lower risk of death.Keywords: ABCB1, SARS-CoV2, drug transporter geneshttps://www.dovepress.com/impact-of-the-abcb1-drug-resistance-gene-on-the-risk-factors-of-patien-peer-reviewed-fulltext-article-IDRabcb1sars-cov2drug transporter genes |
| spellingShingle | Olarte Carrillo I Ramos Peñafiel CO Mendoza Salas I Cerón Maldonado R García Laguna AI De la Cruz Rosas A Martinez Murrillo C Martinez Tovar A Impact of the ABCB1 Drug Resistance Gene on the Risk Factors of Patients with COVID-19 and Its Relationship with the Drugs Used Infection and Drug Resistance abcb1 sars-cov2 drug transporter genes |
| title | Impact of the ABCB1 Drug Resistance Gene on the Risk Factors of Patients with COVID-19 and Its Relationship with the Drugs Used |
| title_full | Impact of the ABCB1 Drug Resistance Gene on the Risk Factors of Patients with COVID-19 and Its Relationship with the Drugs Used |
| title_fullStr | Impact of the ABCB1 Drug Resistance Gene on the Risk Factors of Patients with COVID-19 and Its Relationship with the Drugs Used |
| title_full_unstemmed | Impact of the ABCB1 Drug Resistance Gene on the Risk Factors of Patients with COVID-19 and Its Relationship with the Drugs Used |
| title_short | Impact of the ABCB1 Drug Resistance Gene on the Risk Factors of Patients with COVID-19 and Its Relationship with the Drugs Used |
| title_sort | impact of the abcb1 drug resistance gene on the risk factors of patients with covid 19 and its relationship with the drugs used |
| topic | abcb1 sars-cov2 drug transporter genes |
| url | https://www.dovepress.com/impact-of-the-abcb1-drug-resistance-gene-on-the-risk-factors-of-patien-peer-reviewed-fulltext-article-IDR |
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