Recent Developments in Ion-Sensitive Systems for Pharmaceutical Applications
Stimuli-responsive carriers of pharmaceutical agents have been extensively researched in recent decades due to the possibility of distinctively precise targeted drug delivery. One of the potentially beneficial strategies is based on the response of the medical device to changes in the ionic environm...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/13/10/1641 |
| _version_ | 1797533637641502720 |
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| author | Michał Rudko Tomasz Urbaniak Witold Musiał |
| author_facet | Michał Rudko Tomasz Urbaniak Witold Musiał |
| author_sort | Michał Rudko |
| collection | DOAJ |
| description | Stimuli-responsive carriers of pharmaceutical agents have been extensively researched in recent decades due to the possibility of distinctively precise targeted drug delivery. One of the potentially beneficial strategies is based on the response of the medical device to changes in the ionic environment. Fluctuations in ionic strength and ionic composition associated with pathological processes may provide triggers sufficient to induce an advantageous carrier response. This review is focused on recent developments and novel strategies in the design of ion-responsive drug delivery systems. A variety of structures i.e., polymeric matrices, lipid carriers, nucleoside constructs, and metal-organic frameworks, were included in the scope of the summary. Recently proposed strategies aim to induce different pharmaceutically beneficial effects: localized drug release in the desired manner, mucoadhesive properties, increased residence time, or diagnostic signal emission. The current state of development of ion-sensitive drug delivery systems enabled the marketing of some responsive topical formulations. Concurrently, ongoing research is focused on more selective and complex systems for different administration routes. The potential benefits in therapeutic efficacy and safety associated with the employment of multi-responsive systems will prospectively result in further research and applicable solutions. |
| first_indexed | 2024-03-10T11:17:27Z |
| format | Article |
| id | doaj.art-c515346c41f4491baf69e69d14f27ffc |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T11:17:27Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-c515346c41f4491baf69e69d14f27ffc2023-11-21T20:20:01ZengMDPI AGPolymers2073-43602021-05-011310164110.3390/polym13101641Recent Developments in Ion-Sensitive Systems for Pharmaceutical ApplicationsMichał Rudko0Tomasz Urbaniak1Witold Musiał2Department of Physical Chemistry and Biophysics, Pharmaceutical Faculty, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, PolandDepartment of Physical Chemistry and Biophysics, Pharmaceutical Faculty, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, PolandDepartment of Physical Chemistry and Biophysics, Pharmaceutical Faculty, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, PolandStimuli-responsive carriers of pharmaceutical agents have been extensively researched in recent decades due to the possibility of distinctively precise targeted drug delivery. One of the potentially beneficial strategies is based on the response of the medical device to changes in the ionic environment. Fluctuations in ionic strength and ionic composition associated with pathological processes may provide triggers sufficient to induce an advantageous carrier response. This review is focused on recent developments and novel strategies in the design of ion-responsive drug delivery systems. A variety of structures i.e., polymeric matrices, lipid carriers, nucleoside constructs, and metal-organic frameworks, were included in the scope of the summary. Recently proposed strategies aim to induce different pharmaceutically beneficial effects: localized drug release in the desired manner, mucoadhesive properties, increased residence time, or diagnostic signal emission. The current state of development of ion-sensitive drug delivery systems enabled the marketing of some responsive topical formulations. Concurrently, ongoing research is focused on more selective and complex systems for different administration routes. The potential benefits in therapeutic efficacy and safety associated with the employment of multi-responsive systems will prospectively result in further research and applicable solutions.https://www.mdpi.com/2073-4360/13/10/1641ion-sensitive systemsdrug deliverysmart pharmaceutical systemsbiocompatible medical devices |
| spellingShingle | Michał Rudko Tomasz Urbaniak Witold Musiał Recent Developments in Ion-Sensitive Systems for Pharmaceutical Applications Polymers ion-sensitive systems drug delivery smart pharmaceutical systems biocompatible medical devices |
| title | Recent Developments in Ion-Sensitive Systems for Pharmaceutical Applications |
| title_full | Recent Developments in Ion-Sensitive Systems for Pharmaceutical Applications |
| title_fullStr | Recent Developments in Ion-Sensitive Systems for Pharmaceutical Applications |
| title_full_unstemmed | Recent Developments in Ion-Sensitive Systems for Pharmaceutical Applications |
| title_short | Recent Developments in Ion-Sensitive Systems for Pharmaceutical Applications |
| title_sort | recent developments in ion sensitive systems for pharmaceutical applications |
| topic | ion-sensitive systems drug delivery smart pharmaceutical systems biocompatible medical devices |
| url | https://www.mdpi.com/2073-4360/13/10/1641 |
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