Humoral immune responses against SARS-CoV-2 Spike variants after mRNA vaccination in solid organ transplant recipients
Summary: Although SARS-CoV-2 mRNA vaccination has been shown to be safe and effective in the general population, immunocompromised solid organ transplant recipients (SOTRs) were reported to have impaired immune responses after one or two doses of vaccine. In this study, we examined humoral responses...
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Format: | Article |
Language: | English |
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Elsevier
2022-09-01
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Series: | iScience |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222012627 |
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author | Alexandra Tauzin Guillaume Beaudoin-Bussières Shang Yu Gong Debashree Chatterjee Gabrielle Gendron-Lepage Catherine Bourassa Guillaume Goyette Normand Racine Zineb Khrifi Julie Turgeon Cécile Tremblay Valérie Martel-Laferrière Daniel E. Kaufmann Héloïse Cardinal Marc Cloutier Renée Bazin Ralf Duerr Mélanie Dieudé Marie-Josée Hébert Andrés Finzi |
author_facet | Alexandra Tauzin Guillaume Beaudoin-Bussières Shang Yu Gong Debashree Chatterjee Gabrielle Gendron-Lepage Catherine Bourassa Guillaume Goyette Normand Racine Zineb Khrifi Julie Turgeon Cécile Tremblay Valérie Martel-Laferrière Daniel E. Kaufmann Héloïse Cardinal Marc Cloutier Renée Bazin Ralf Duerr Mélanie Dieudé Marie-Josée Hébert Andrés Finzi |
author_sort | Alexandra Tauzin |
collection | DOAJ |
description | Summary: Although SARS-CoV-2 mRNA vaccination has been shown to be safe and effective in the general population, immunocompromised solid organ transplant recipients (SOTRs) were reported to have impaired immune responses after one or two doses of vaccine. In this study, we examined humoral responses induced after the second and the third dose of mRNA vaccine in different SOTR (kidney, liver, lung, and heart). Compared to a cohort of SARS-CoV-2 naïve immunocompetent health care workers (HCWs), the second dose induced weak humoral responses in SOTRs, except for the liver recipients. The third dose boosted these responses but they did not reach the same level as in HCW. Interestingly, although the neutralizing activity against Delta and Omicron variants remained very low after the third dose, Fc-mediated effector functions in SOTR reached similar levels as in the HCW cohort. Whether these responses will suffice to protect SOTR from severe outcome remains to be determined. |
first_indexed | 2024-04-11T21:25:12Z |
format | Article |
id | doaj.art-c515ec76f27640b58bc73f10fe68503f |
institution | Directory Open Access Journal |
issn | 2589-0042 |
language | English |
last_indexed | 2024-04-11T21:25:12Z |
publishDate | 2022-09-01 |
publisher | Elsevier |
record_format | Article |
series | iScience |
spelling | doaj.art-c515ec76f27640b58bc73f10fe68503f2022-12-22T04:02:27ZengElsevieriScience2589-00422022-09-01259104990Humoral immune responses against SARS-CoV-2 Spike variants after mRNA vaccination in solid organ transplant recipientsAlexandra Tauzin0Guillaume Beaudoin-Bussières1Shang Yu Gong2Debashree Chatterjee3Gabrielle Gendron-Lepage4Catherine Bourassa5Guillaume Goyette6Normand Racine7Zineb Khrifi8Julie Turgeon9Cécile Tremblay10Valérie Martel-Laferrière11Daniel E. Kaufmann12Héloïse Cardinal13Marc Cloutier14Renée Bazin15Ralf Duerr16Mélanie Dieudé17Marie-Josée Hébert18Andrés Finzi19Centre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, CanadaCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, CanadaCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, CanadaCentre de Recherche du CHUM, Montreal, QC H2X 0A9, CanadaCentre de Recherche du CHUM, Montreal, QC H2X 0A9, CanadaCentre de Recherche du CHUM, Montreal, QC H2X 0A9, CanadaCentre de Recherche du CHUM, Montreal, QC H2X 0A9, CanadaInstitut Cardiologie de Montréal, Montreal, QC H1T 1C8, CanadaCentre de Recherche du CHUM, Montreal, QC H2X 0A9, CanadaCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Canadian Donation and Transplantation Research Program (CDTRP), Edmonton, AL T6G 2E1, CanadaCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, CanadaCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, CanadaCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Médecine, Université de Montréal, Montreal, QC H3T 1J4, CanadaCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada; Canadian Donation and Transplantation Research Program (CDTRP), Edmonton, AL T6G 2E1, CanadaHéma-Québec, Affaires Médicales et Innovation, Québec, QC G1V 5C3, CanadaHéma-Québec, Affaires Médicales et Innovation, Québec, QC G1V 5C3, CanadaDepartment of Microbiology, New York University School of Medicine, New York, NY 10016, USACentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada; Canadian Donation and Transplantation Research Program (CDTRP), Edmonton, AL T6G 2E1, Canada; Héma-Québec, Affaires Médicales et Innovation, Québec, QC G1V 5C3, CanadaCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Canadian Donation and Transplantation Research Program (CDTRP), Edmonton, AL T6G 2E1, Canada; Département de Médecine, Université de Montréal, Montreal, QC H3T 1J4, Canada; Corresponding authorCentre de Recherche du CHUM, Montreal, QC H2X 0A9, Canada; Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, QC H2X 0A9, Canada; Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada; Corresponding authorSummary: Although SARS-CoV-2 mRNA vaccination has been shown to be safe and effective in the general population, immunocompromised solid organ transplant recipients (SOTRs) were reported to have impaired immune responses after one or two doses of vaccine. In this study, we examined humoral responses induced after the second and the third dose of mRNA vaccine in different SOTR (kidney, liver, lung, and heart). Compared to a cohort of SARS-CoV-2 naïve immunocompetent health care workers (HCWs), the second dose induced weak humoral responses in SOTRs, except for the liver recipients. The third dose boosted these responses but they did not reach the same level as in HCW. Interestingly, although the neutralizing activity against Delta and Omicron variants remained very low after the third dose, Fc-mediated effector functions in SOTR reached similar levels as in the HCW cohort. Whether these responses will suffice to protect SOTR from severe outcome remains to be determined.http://www.sciencedirect.com/science/article/pii/S2589004222012627SurgeryImmunologyVirology |
spellingShingle | Alexandra Tauzin Guillaume Beaudoin-Bussières Shang Yu Gong Debashree Chatterjee Gabrielle Gendron-Lepage Catherine Bourassa Guillaume Goyette Normand Racine Zineb Khrifi Julie Turgeon Cécile Tremblay Valérie Martel-Laferrière Daniel E. Kaufmann Héloïse Cardinal Marc Cloutier Renée Bazin Ralf Duerr Mélanie Dieudé Marie-Josée Hébert Andrés Finzi Humoral immune responses against SARS-CoV-2 Spike variants after mRNA vaccination in solid organ transplant recipients iScience Surgery Immunology Virology |
title | Humoral immune responses against SARS-CoV-2 Spike variants after mRNA vaccination in solid organ transplant recipients |
title_full | Humoral immune responses against SARS-CoV-2 Spike variants after mRNA vaccination in solid organ transplant recipients |
title_fullStr | Humoral immune responses against SARS-CoV-2 Spike variants after mRNA vaccination in solid organ transplant recipients |
title_full_unstemmed | Humoral immune responses against SARS-CoV-2 Spike variants after mRNA vaccination in solid organ transplant recipients |
title_short | Humoral immune responses against SARS-CoV-2 Spike variants after mRNA vaccination in solid organ transplant recipients |
title_sort | humoral immune responses against sars cov 2 spike variants after mrna vaccination in solid organ transplant recipients |
topic | Surgery Immunology Virology |
url | http://www.sciencedirect.com/science/article/pii/S2589004222012627 |
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