Potential biocide roles of violacein
Violacein is a pigment produced by Gram-negative bacteria, which has shown several beneficial biological activities. The most relevant activities of violacein include the interference in the physiological activities of biological membranes, inhibition of cell proliferation, antioxidant, and anti-inf...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Nanotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnano.2023.1186386/full |
| _version_ | 1797774982118375424 |
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| author | Ignacio Rivero Berti Melisa E. Gantner Santiago Rodriguez German A. Islan Wagner J. Fávaro Alan Talevi Guillermo R. Castro Nelson Durán Nelson Durán |
| author_facet | Ignacio Rivero Berti Melisa E. Gantner Santiago Rodriguez German A. Islan Wagner J. Fávaro Alan Talevi Guillermo R. Castro Nelson Durán Nelson Durán |
| author_sort | Ignacio Rivero Berti |
| collection | DOAJ |
| description | Violacein is a pigment produced by Gram-negative bacteria, which has shown several beneficial biological activities. The most relevant activities of violacein include the interference in the physiological activities of biological membranes, inhibition of cell proliferation, antioxidant, and anti-inflammatory activities. Moreover, the antiviral activities of violacein against some enveloped and non-enveloped viruses have also been reported. Violacein showed a wide spectrum of protease inhibition, both experimentally and in silico. Other in silico studies have suggested that violacein binds to the SARS-CoV-2 spike. Empirical physicochemical studies indicate that violacein (or, occasionally, its derivatives) may be administered orally to treat different disorders. In addition, different alternatives to product violacein, and molecular devices for delivery of this pigment are reviewed. |
| first_indexed | 2024-03-12T22:29:03Z |
| format | Article |
| id | doaj.art-c51801b4278e4fc58d0086f2cccd82cd |
| institution | Directory Open Access Journal |
| issn | 2673-3013 |
| language | English |
| last_indexed | 2024-03-12T22:29:03Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nanotechnology |
| spelling | doaj.art-c51801b4278e4fc58d0086f2cccd82cd2023-07-21T19:32:14ZengFrontiers Media S.A.Frontiers in Nanotechnology2673-30132023-07-01510.3389/fnano.2023.11863861186386Potential biocide roles of violaceinIgnacio Rivero Berti0Melisa E. Gantner1Santiago Rodriguez2German A. Islan3Wagner J. Fávaro4Alan Talevi5Guillermo R. Castro6Nelson Durán7Nelson Durán8Laboratorio de Nanobiomateriales, Centro de Investigación y Desarrollo en Fermentaciones Industriales (CINDEFI), Departamento de Química, Facultad de Ciencias Exactas, CONICET-UNLP (CCT La Plata), La Plata, ArgentinaLaboratorio de Investigación y Desarrollo de Bioactivos (LIDeB), Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP), La Plata, ArgentinaLaboratorio de Investigación y Desarrollo de Bioactivos (LIDeB), Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP), La Plata, ArgentinaLaboratorio de Nanobiomateriales, Centro de Investigación y Desarrollo en Fermentaciones Industriales (CINDEFI), Departamento de Química, Facultad de Ciencias Exactas, CONICET-UNLP (CCT La Plata), La Plata, ArgentinaLaboratory of Basic and Applied Bacteriology, Department of Microbiology, Center of Biological Sciences, Londrina State University, Londrina, BrazilLaboratorio de Investigación y Desarrollo de Bioactivos (LIDeB), Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata (UNLP), La Plata, ArgentinaNanomedicine Research Unit (Nanomed), Center for Natural and Human Sciences, Federal University of ABC (UFABC), São Paulo, BrazilNanomedicine Research Unit (Nanomed), Center for Natural and Human Sciences, Federal University of ABC (UFABC), São Paulo, BrazilLaboratory of Urogenital Carcinogenesis and Immunotherapy, Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, BrazilViolacein is a pigment produced by Gram-negative bacteria, which has shown several beneficial biological activities. The most relevant activities of violacein include the interference in the physiological activities of biological membranes, inhibition of cell proliferation, antioxidant, and anti-inflammatory activities. Moreover, the antiviral activities of violacein against some enveloped and non-enveloped viruses have also been reported. Violacein showed a wide spectrum of protease inhibition, both experimentally and in silico. Other in silico studies have suggested that violacein binds to the SARS-CoV-2 spike. Empirical physicochemical studies indicate that violacein (or, occasionally, its derivatives) may be administered orally to treat different disorders. In addition, different alternatives to product violacein, and molecular devices for delivery of this pigment are reviewed.https://www.frontiersin.org/articles/10.3389/fnano.2023.1186386/fullviolaceinCOVID-19membrane interactionantioxidant activityanti-inflammatory activityprotease inhibition |
| spellingShingle | Ignacio Rivero Berti Melisa E. Gantner Santiago Rodriguez German A. Islan Wagner J. Fávaro Alan Talevi Guillermo R. Castro Nelson Durán Nelson Durán Potential biocide roles of violacein Frontiers in Nanotechnology violacein COVID-19 membrane interaction antioxidant activity anti-inflammatory activity protease inhibition |
| title | Potential biocide roles of violacein |
| title_full | Potential biocide roles of violacein |
| title_fullStr | Potential biocide roles of violacein |
| title_full_unstemmed | Potential biocide roles of violacein |
| title_short | Potential biocide roles of violacein |
| title_sort | potential biocide roles of violacein |
| topic | violacein COVID-19 membrane interaction antioxidant activity anti-inflammatory activity protease inhibition |
| url | https://www.frontiersin.org/articles/10.3389/fnano.2023.1186386/full |
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