METTL1 mediated tRNA m7G modification promotes leukaemogenesis of AML via tRNA regulated translational control

METTL1 mediated tRNA m7G modification promotes leukaemogenesis of AML via tRNA regulated translational control

Abstract Background RNA modifications have been proven to play fundamental roles in regulating cellular biology process. Recently, maladjusted N7-methylguanosine (m7G) modification and its modifiers METTL1/WDR4 have been confirmed an oncogene role in multiple cancers. However, the functions and mole...

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Bibliographic Details
Main Authors: Pan Zhao, Lin Xia, Dan Chen, Wei Xu, Huanping Guo, Yinying Xu, Bingbing Yan, Xiao Wu, Yuxia Li, Yunfang Zhang, Xi Zhang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Experimental Hematology & Oncology
Subjects:
METTL1/WDR4
tRNA modification
m7G
AML
Translation control
Online Access:https://doi.org/10.1186/s40164-024-00477-8

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