The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer
The Integrated Stress Response (ISR) is a cytoprotective pathway upregulated in many cancers. Here the authors show that the activation of PERK/p-eIF2α arm of ISR enhances ERK phosphorylation through translation repression of DUSP6, thus resulting in KRAS-driven lung tumorigenesis.
Bibliographic Details
| Main Authors: |
Nour Ghaddar,
Shuo Wang,
Bethany Woodvine,
Jothilatha Krishnamoorthy,
Vincent van Hoef,
Cedric Darini,
Urszula Kazimierczak,
Nicolas Ah-son,
Helmuth Popper,
Myriam Johnson,
Leah Officer,
Ana Teodósio,
Massimo Broggini,
Koren K. Mann,
Maria Hatzoglou,
Ivan Topisirovic,
Ola Larsson,
John Le Quesne,
Antonis E. Koromilas |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-24661-0
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