Ameliorative Effects of Loganin on Arthritis in Chondrocytes and Destabilization of the Medial Meniscus-Induced Animal Model
Arthritis is a common inflammatory disease that causes pain, stiffness, and joint swelling. Here, we investigated the ameliorative effects of loganin on arthritis in vitro and in vivo. A single bioactive compound was fractionated and isolated from <i>Cornus officinalis</i> (CO) extract t...
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MDPI AG
2021-02-01
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| Online Access: | https://www.mdpi.com/1424-8247/14/2/135 |
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| author | Eunkuk Park Chang Gun Lee Seung Hee Yun Seokjin Hwang Hyoju Jeon Jeonghyun Kim Subin Yeo Hyesoo Jeong Seong-Hoon Yun Seon-Yong Jeong |
| author_facet | Eunkuk Park Chang Gun Lee Seung Hee Yun Seokjin Hwang Hyoju Jeon Jeonghyun Kim Subin Yeo Hyesoo Jeong Seong-Hoon Yun Seon-Yong Jeong |
| author_sort | Eunkuk Park |
| collection | DOAJ |
| description | Arthritis is a common inflammatory disease that causes pain, stiffness, and joint swelling. Here, we investigated the ameliorative effects of loganin on arthritis in vitro and in vivo. A single bioactive compound was fractionated and isolated from <i>Cornus officinalis</i> (CO) extract to screen for anti-arthritic effects. A single component, loganin, was identified as a candidate. The CO extract and loganin inhibited the expression of factors associated with cartilage degradation, such as cyclooxygenase-2 (COX-2), matrix metalloproteinase 3 (MMP-3), and matrix metalloproteinase 13 (MMP-13), in interukin-1 beta (IL-1β)-induced chondrocyte inflammation. In addition, prostaglandin and collagenase levels were reduced following treatment of IL-1β-induced chondrocytes with loganin. In the destabilization of the medial meniscus (DMM)-induced mouse model, loganin administration attenuated cartilage degeneration by inhibiting COX-2, MMP-3, and MMP-13. Transverse micro-CT images revealed that loganin reduced DMM-induced osteophyte formation. These results indicate that loganin has protective effects in DMM-induced mice. |
| first_indexed | 2024-03-09T05:10:24Z |
| format | Article |
| id | doaj.art-c518c8715fd8401c85c4405ca6b27218 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T05:10:24Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-c518c8715fd8401c85c4405ca6b272182023-12-03T12:50:21ZengMDPI AGPharmaceuticals1424-82472021-02-0114213510.3390/ph14020135Ameliorative Effects of Loganin on Arthritis in Chondrocytes and Destabilization of the Medial Meniscus-Induced Animal ModelEunkuk Park0Chang Gun Lee1Seung Hee Yun2Seokjin Hwang3Hyoju Jeon4Jeonghyun Kim5Subin Yeo6Hyesoo Jeong7Seong-Hoon Yun8Seon-Yong Jeong9Department of Medical Genetics, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Medical Genetics, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Medical Genetics, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Medical Genetics, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Medical Genetics, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Medical Genetics, Ajou University School of Medicine, Suwon 16499, KoreaNine B Co. Ltd., Daejeon 34121, KoreaNine B Co. Ltd., Daejeon 34121, KoreaNine B Co. Ltd., Daejeon 34121, KoreaDepartment of Medical Genetics, Ajou University School of Medicine, Suwon 16499, KoreaArthritis is a common inflammatory disease that causes pain, stiffness, and joint swelling. Here, we investigated the ameliorative effects of loganin on arthritis in vitro and in vivo. A single bioactive compound was fractionated and isolated from <i>Cornus officinalis</i> (CO) extract to screen for anti-arthritic effects. A single component, loganin, was identified as a candidate. The CO extract and loganin inhibited the expression of factors associated with cartilage degradation, such as cyclooxygenase-2 (COX-2), matrix metalloproteinase 3 (MMP-3), and matrix metalloproteinase 13 (MMP-13), in interukin-1 beta (IL-1β)-induced chondrocyte inflammation. In addition, prostaglandin and collagenase levels were reduced following treatment of IL-1β-induced chondrocytes with loganin. In the destabilization of the medial meniscus (DMM)-induced mouse model, loganin administration attenuated cartilage degeneration by inhibiting COX-2, MMP-3, and MMP-13. Transverse micro-CT images revealed that loganin reduced DMM-induced osteophyte formation. These results indicate that loganin has protective effects in DMM-induced mice.https://www.mdpi.com/1424-8247/14/2/135arthritis<i>Cornus officinalis</i>loganindestabilization of the medial meniscusanti-inflammatory effect |
| spellingShingle | Eunkuk Park Chang Gun Lee Seung Hee Yun Seokjin Hwang Hyoju Jeon Jeonghyun Kim Subin Yeo Hyesoo Jeong Seong-Hoon Yun Seon-Yong Jeong Ameliorative Effects of Loganin on Arthritis in Chondrocytes and Destabilization of the Medial Meniscus-Induced Animal Model Pharmaceuticals arthritis <i>Cornus officinalis</i> loganin destabilization of the medial meniscus anti-inflammatory effect |
| title | Ameliorative Effects of Loganin on Arthritis in Chondrocytes and Destabilization of the Medial Meniscus-Induced Animal Model |
| title_full | Ameliorative Effects of Loganin on Arthritis in Chondrocytes and Destabilization of the Medial Meniscus-Induced Animal Model |
| title_fullStr | Ameliorative Effects of Loganin on Arthritis in Chondrocytes and Destabilization of the Medial Meniscus-Induced Animal Model |
| title_full_unstemmed | Ameliorative Effects of Loganin on Arthritis in Chondrocytes and Destabilization of the Medial Meniscus-Induced Animal Model |
| title_short | Ameliorative Effects of Loganin on Arthritis in Chondrocytes and Destabilization of the Medial Meniscus-Induced Animal Model |
| title_sort | ameliorative effects of loganin on arthritis in chondrocytes and destabilization of the medial meniscus induced animal model |
| topic | arthritis <i>Cornus officinalis</i> loganin destabilization of the medial meniscus anti-inflammatory effect |
| url | https://www.mdpi.com/1424-8247/14/2/135 |
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