Recent Advances in Understanding, Diagnosing, and Treating Hepatitis B Virus Infection
Chronic hepatitis B virus (HBV) infection affects 292 million people worldwide and is associated with a broad range of clinical manifestations including cirrhosis, liver failure, and hepatocellular carcinoma (HCC). Despite the availability of an effective vaccine HBV still causes nearly 900,000 deat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/8/9/1416 |
| _version_ | 1797553673814933504 |
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| author | Magda Rybicka Krzysztof Piotr Bielawski |
| author_facet | Magda Rybicka Krzysztof Piotr Bielawski |
| author_sort | Magda Rybicka |
| collection | DOAJ |
| description | Chronic hepatitis B virus (HBV) infection affects 292 million people worldwide and is associated with a broad range of clinical manifestations including cirrhosis, liver failure, and hepatocellular carcinoma (HCC). Despite the availability of an effective vaccine HBV still causes nearly 900,000 deaths every year. Current treatment options keep HBV under control, but they do not offer a cure as they cannot completely clear HBV from infected hepatocytes. The recent development of reliable cell culture systems allowed for a better understanding of the host and viral mechanisms affecting HBV replication and persistence. Recent advances into the understanding of HBV biology, new potential diagnostic markers of hepatitis B infection, as well as novel antivirals targeting different steps in the HBV replication cycle are summarized in this review article. |
| first_indexed | 2024-03-10T16:19:57Z |
| format | Article |
| id | doaj.art-c519c27f0e55490ebd7b162cfec80ae9 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T16:19:57Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-c519c27f0e55490ebd7b162cfec80ae92023-11-20T13:46:34ZengMDPI AGMicroorganisms2076-26072020-09-0189141610.3390/microorganisms8091416Recent Advances in Understanding, Diagnosing, and Treating Hepatitis B Virus InfectionMagda Rybicka0Krzysztof Piotr Bielawski1Department of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, PolandDepartment of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, PolandChronic hepatitis B virus (HBV) infection affects 292 million people worldwide and is associated with a broad range of clinical manifestations including cirrhosis, liver failure, and hepatocellular carcinoma (HCC). Despite the availability of an effective vaccine HBV still causes nearly 900,000 deaths every year. Current treatment options keep HBV under control, but they do not offer a cure as they cannot completely clear HBV from infected hepatocytes. The recent development of reliable cell culture systems allowed for a better understanding of the host and viral mechanisms affecting HBV replication and persistence. Recent advances into the understanding of HBV biology, new potential diagnostic markers of hepatitis B infection, as well as novel antivirals targeting different steps in the HBV replication cycle are summarized in this review article.https://www.mdpi.com/2076-2607/8/9/1416HBVHBV RNAHBcrAgnovel viral markersdirect-acting antivirals |
| spellingShingle | Magda Rybicka Krzysztof Piotr Bielawski Recent Advances in Understanding, Diagnosing, and Treating Hepatitis B Virus Infection Microorganisms HBV HBV RNA HBcrAg novel viral markers direct-acting antivirals |
| title | Recent Advances in Understanding, Diagnosing, and Treating Hepatitis B Virus Infection |
| title_full | Recent Advances in Understanding, Diagnosing, and Treating Hepatitis B Virus Infection |
| title_fullStr | Recent Advances in Understanding, Diagnosing, and Treating Hepatitis B Virus Infection |
| title_full_unstemmed | Recent Advances in Understanding, Diagnosing, and Treating Hepatitis B Virus Infection |
| title_short | Recent Advances in Understanding, Diagnosing, and Treating Hepatitis B Virus Infection |
| title_sort | recent advances in understanding diagnosing and treating hepatitis b virus infection |
| topic | HBV HBV RNA HBcrAg novel viral markers direct-acting antivirals |
| url | https://www.mdpi.com/2076-2607/8/9/1416 |
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