A Randomized Assessor-Blinded Wait-List-Controlled Trial to Assess the Effectiveness of Acupuncture in the Management of Chemotherapy-Induced Peripheral Neuropathy
Purpose: Chemotherapy-induced peripheral neuropathy is a complex side effect with few available treatment options. The aim of the study was to test the effectiveness of an 8-week course of acupuncture in the management of chemotherapy-induced peripheral neuropathy in cancer patients who were receivi...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-03-01
|
| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/1534735419836501 |
| _version_ | 1818178749115400192 |
|---|---|
| author | Alexander Molassiotis RN, PhD Lorna K. P. Suen RN, PhD Hui Lin Cheng RN, PhD T. S. K. Mok MD Sara C. Y. Lee MSc C. H. Wang MD Paul Lee PhD Howan Leung MBBS V. Chan MD T. K. H. Lau MD Winnie Yeo MD |
| author_facet | Alexander Molassiotis RN, PhD Lorna K. P. Suen RN, PhD Hui Lin Cheng RN, PhD T. S. K. Mok MD Sara C. Y. Lee MSc C. H. Wang MD Paul Lee PhD Howan Leung MBBS V. Chan MD T. K. H. Lau MD Winnie Yeo MD |
| author_sort | Alexander Molassiotis RN, PhD |
| collection | DOAJ |
| description | Purpose: Chemotherapy-induced peripheral neuropathy is a complex side effect with few available treatment options. The aim of the study was to test the effectiveness of an 8-week course of acupuncture in the management of chemotherapy-induced peripheral neuropathy in cancer patients who were receiving or had received neurotoxic chemotherapy. Methods: Randomized assessor-blinded controlled trial with 2 arms; one arm received acupuncture twice weekly for 8 weeks, while the other arm was a wait-list control group receiving only standard care. Primary outcome was pain intensity and interference over the past week using the Brief Pain Inventory at the end of the intervention. Secondary outcomes included clinical assessment (CTCAE [Common Toxicity Criteria for Adverse Events] grading and Total Neuropathy Score–Clinical Version) and nerve conduction studies; and patient-reported outcome measures (Functional Assessment of Cancer Therapy–Gynecologic Oncology Group–Neurotoxicity Quality of Life scale and Symptom Distress Scale) assessed at baseline, end of treatment (8 weeks), week 14, and week 20 from the beginning of treatment. Results: Eighty-seven patients were randomized to the experimental arm (n = 44) and to the standard care wait-list control arm (n = 43). Significant changes at 8 weeks were detected in relation to primary outcome (pain), the clinical neurological assessment, quality of life domains, and symptom distress (all P < .05). Improvements in pain interference, neurotoxicity-related symptoms, and functional aspects of quality of life were sustained in the 14-week assessment ( P < .05), as were physical and functional well-being at the 20-week assessment ( P < .05). Conclusions: Acupuncture is an effective intervention for treating chemotherapy-induced peripheral neuropathy and improving patients’ quality of life and experience with neurotoxicity-related symptoms with longer term effects evident. |
| first_indexed | 2024-12-11T20:52:55Z |
| format | Article |
| id | doaj.art-c51b86b265b4417d8fea150643767467 |
| institution | Directory Open Access Journal |
| issn | 1552-695X |
| language | English |
| last_indexed | 2024-12-11T20:52:55Z |
| publishDate | 2019-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj.art-c51b86b265b4417d8fea1506437674672022-12-22T00:51:11ZengSAGE PublishingIntegrative Cancer Therapies1552-695X2019-03-011810.1177/1534735419836501A Randomized Assessor-Blinded Wait-List-Controlled Trial to Assess the Effectiveness of Acupuncture in the Management of Chemotherapy-Induced Peripheral NeuropathyAlexander Molassiotis RN, PhD0Lorna K. P. Suen RN, PhD1Hui Lin Cheng RN, PhD2T. S. K. Mok MD3Sara C. Y. Lee MSc4C. H. Wang MD5Paul Lee PhD6Howan Leung MBBS7V. Chan MD8T. K. H. Lau MD9Winnie Yeo MD10The Hong Kong Polytechnic University, Kowloon, Hong Kong SARThe Hong Kong Polytechnic University, Kowloon, Hong Kong SARThe Hong Kong Polytechnic University, Kowloon, Hong Kong SARPrince of Wales Hospital, Sha Tin, Hong Kong SARThe Hong Kong Polytechnic University, Kowloon, Hong Kong SARPrince of Wales Hospital, Sha Tin, Hong Kong SARThe Hong Kong Polytechnic University, Kowloon, Hong Kong SARPrince of Wales Hospital, Sha Tin, Hong Kong SARPrince of Wales Hospital, Sha Tin, Hong Kong SARPrince of Wales Hospital, Sha Tin, Hong Kong SARPrince of Wales Hospital, Sha Tin, Hong Kong SARPurpose: Chemotherapy-induced peripheral neuropathy is a complex side effect with few available treatment options. The aim of the study was to test the effectiveness of an 8-week course of acupuncture in the management of chemotherapy-induced peripheral neuropathy in cancer patients who were receiving or had received neurotoxic chemotherapy. Methods: Randomized assessor-blinded controlled trial with 2 arms; one arm received acupuncture twice weekly for 8 weeks, while the other arm was a wait-list control group receiving only standard care. Primary outcome was pain intensity and interference over the past week using the Brief Pain Inventory at the end of the intervention. Secondary outcomes included clinical assessment (CTCAE [Common Toxicity Criteria for Adverse Events] grading and Total Neuropathy Score–Clinical Version) and nerve conduction studies; and patient-reported outcome measures (Functional Assessment of Cancer Therapy–Gynecologic Oncology Group–Neurotoxicity Quality of Life scale and Symptom Distress Scale) assessed at baseline, end of treatment (8 weeks), week 14, and week 20 from the beginning of treatment. Results: Eighty-seven patients were randomized to the experimental arm (n = 44) and to the standard care wait-list control arm (n = 43). Significant changes at 8 weeks were detected in relation to primary outcome (pain), the clinical neurological assessment, quality of life domains, and symptom distress (all P < .05). Improvements in pain interference, neurotoxicity-related symptoms, and functional aspects of quality of life were sustained in the 14-week assessment ( P < .05), as were physical and functional well-being at the 20-week assessment ( P < .05). Conclusions: Acupuncture is an effective intervention for treating chemotherapy-induced peripheral neuropathy and improving patients’ quality of life and experience with neurotoxicity-related symptoms with longer term effects evident.https://doi.org/10.1177/1534735419836501 |
| spellingShingle | Alexander Molassiotis RN, PhD Lorna K. P. Suen RN, PhD Hui Lin Cheng RN, PhD T. S. K. Mok MD Sara C. Y. Lee MSc C. H. Wang MD Paul Lee PhD Howan Leung MBBS V. Chan MD T. K. H. Lau MD Winnie Yeo MD A Randomized Assessor-Blinded Wait-List-Controlled Trial to Assess the Effectiveness of Acupuncture in the Management of Chemotherapy-Induced Peripheral Neuropathy Integrative Cancer Therapies |
| title | A Randomized Assessor-Blinded Wait-List-Controlled Trial to Assess the Effectiveness of Acupuncture in the Management of Chemotherapy-Induced Peripheral Neuropathy |
| title_full | A Randomized Assessor-Blinded Wait-List-Controlled Trial to Assess the Effectiveness of Acupuncture in the Management of Chemotherapy-Induced Peripheral Neuropathy |
| title_fullStr | A Randomized Assessor-Blinded Wait-List-Controlled Trial to Assess the Effectiveness of Acupuncture in the Management of Chemotherapy-Induced Peripheral Neuropathy |
| title_full_unstemmed | A Randomized Assessor-Blinded Wait-List-Controlled Trial to Assess the Effectiveness of Acupuncture in the Management of Chemotherapy-Induced Peripheral Neuropathy |
| title_short | A Randomized Assessor-Blinded Wait-List-Controlled Trial to Assess the Effectiveness of Acupuncture in the Management of Chemotherapy-Induced Peripheral Neuropathy |
| title_sort | randomized assessor blinded wait list controlled trial to assess the effectiveness of acupuncture in the management of chemotherapy induced peripheral neuropathy |
| url | https://doi.org/10.1177/1534735419836501 |
| work_keys_str_mv | AT alexandermolassiotisrnphd arandomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT lornakpsuenrnphd arandomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT huilinchengrnphd arandomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT tskmokmd arandomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT saracyleemsc arandomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT chwangmd arandomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT paulleephd arandomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT howanleungmbbs arandomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT vchanmd arandomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT tkhlaumd arandomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT winnieyeomd arandomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT alexandermolassiotisrnphd randomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT lornakpsuenrnphd randomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT huilinchengrnphd randomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT tskmokmd randomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT saracyleemsc randomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT chwangmd randomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT paulleephd randomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT howanleungmbbs randomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT vchanmd randomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT tkhlaumd randomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy AT winnieyeomd randomizedassessorblindedwaitlistcontrolledtrialtoassesstheeffectivenessofacupunctureinthemanagementofchemotherapyinducedperipheralneuropathy |