TRPA1-dependent and -independent activation by commonly used preservatives

TRPA1-dependent and -independent activation by commonly used preservatives

Background and purpose: Addition of preservatives ensures microbial stability, especially in multidose containers of parenterally administered pharmaceuticals. These compounds can cause side effects, and particularly at the site of application, might elicit or facilitate pain. TRPA1 is a cation chan...

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Bibliographic Details
Main Authors: Maximilian L. Mager, Cosmin I. Ciotu, Markus Gold-Binder, Stefan Heber, Michael J. M. Fischer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Pharmacology
Subjects:
TRPA1
preservative
inflammation
sensitisation
pain
TRP channel
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1248558/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1248558/full

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