Suppression of TET1-Dependent DNA Demethylation Is Essential for KRAS-Mediated Transformation

Suppression of TET1-Dependent DNA Demethylation Is Essential for KRAS-Mediated Transformation

Summary: Hypermethylation-mediated tumor suppressor gene (TSG) silencing is a central epigenetic alteration in RAS-dependent tumorigenesis. Ten-eleven translocation (TET) enzymes can depress DNA methylation by hydroxylation of 5-methylcytosine (5mC) bases to 5-hydroxymethylcytosine (5hmC). Here, we...

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Bibliographic Details
Main Authors:	Bo-Kuan Wu, Charles Brenner
Format:	Article
Language:	English
Published:	Elsevier 2014-12-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124714009322

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