Clinicopathological profile of hepatoblastoma: An experience from a tertiary care center in India
Background: Hepatoblastoma is the most common primary hepatic malignancy in the pediatric population. Advances in pathological evaluation, imaging, risk stratification, neo-adjuvant chemotherapy, and surgery including transplantation have improved survival of these children in the western countries....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2019;volume=62;issue=4;spage=556;epage=560;aulast=Archana |
| _version_ | 1818251750510952448 |
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| author | B Archana J Thanka Latha M Sneha J Julius Xavier Scott M Arunan Prakash Agarwal |
| author_facet | B Archana J Thanka Latha M Sneha J Julius Xavier Scott M Arunan Prakash Agarwal |
| author_sort | B Archana |
| collection | DOAJ |
| description | Background: Hepatoblastoma is the most common primary hepatic malignancy in the pediatric population. Advances in pathological evaluation, imaging, risk stratification, neo-adjuvant chemotherapy, and surgery including transplantation have improved survival of these children in the western countries. However, a successful outcome in developing countries such as India with limited resources poses great challenges to the clinician and the family. Histology plays a major role in determining the prognosis of these patients. Methods: A retrospective study was done on 10 children diagnosed with hepatoblastoma between January 2010 and December 2015 in our institution. Clinical, laboratory, radiological, histopathological diagnoses, treatment, and outcome data were collected and analyzed. Results: The median age of these children at diagnosis was 11 months, and only 1 child was premature at birth. Most children were presented with abdominal distension. One child had lung metastasis at presentation. Elevated alpha fetoprotein levels were present in 90% of the children. The histological types were fetal, embryonal, macrotrabecular, and mixed epithelial-mesenchymal types. SIOPEL risk stratification was done, which showed 40% of the children to be of high risk. Three children had PRETEXT 1, 2, and 4, respectively. Conclusion: Our study is significant with respect to the information on PRETEXT staging, risk status, and histological favorability. In developing countries with limited resources and low-socioeconomic status, it is important to have a multidisciplinary team approach and tailor treatment to manage these patients effectively and improve the overall survival. |
| first_indexed | 2024-12-12T16:13:15Z |
| format | Article |
| id | doaj.art-c51ea896ada946639f1abb56aed42807 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-12T16:13:15Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-c51ea896ada946639f1abb56aed428072022-12-22T00:19:09ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292019-01-0162455656010.4103/IJPM.IJPM_200_19Clinicopathological profile of hepatoblastoma: An experience from a tertiary care center in IndiaB ArchanaJ ThankaLatha M SnehaJ Julius Xavier ScottM ArunanPrakash AgarwalBackground: Hepatoblastoma is the most common primary hepatic malignancy in the pediatric population. Advances in pathological evaluation, imaging, risk stratification, neo-adjuvant chemotherapy, and surgery including transplantation have improved survival of these children in the western countries. However, a successful outcome in developing countries such as India with limited resources poses great challenges to the clinician and the family. Histology plays a major role in determining the prognosis of these patients. Methods: A retrospective study was done on 10 children diagnosed with hepatoblastoma between January 2010 and December 2015 in our institution. Clinical, laboratory, radiological, histopathological diagnoses, treatment, and outcome data were collected and analyzed. Results: The median age of these children at diagnosis was 11 months, and only 1 child was premature at birth. Most children were presented with abdominal distension. One child had lung metastasis at presentation. Elevated alpha fetoprotein levels were present in 90% of the children. The histological types were fetal, embryonal, macrotrabecular, and mixed epithelial-mesenchymal types. SIOPEL risk stratification was done, which showed 40% of the children to be of high risk. Three children had PRETEXT 1, 2, and 4, respectively. Conclusion: Our study is significant with respect to the information on PRETEXT staging, risk status, and histological favorability. In developing countries with limited resources and low-socioeconomic status, it is important to have a multidisciplinary team approach and tailor treatment to manage these patients effectively and improve the overall survival.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2019;volume=62;issue=4;spage=556;epage=560;aulast=ArchanaAlpha fetoproteinhepatoblastomahistologyPRETEXT |
| spellingShingle | B Archana J Thanka Latha M Sneha J Julius Xavier Scott M Arunan Prakash Agarwal Clinicopathological profile of hepatoblastoma: An experience from a tertiary care center in India Indian Journal of Pathology and Microbiology Alpha fetoprotein hepatoblastoma histology PRETEXT |
| title | Clinicopathological profile of hepatoblastoma: An experience from a tertiary care center in India |
| title_full | Clinicopathological profile of hepatoblastoma: An experience from a tertiary care center in India |
| title_fullStr | Clinicopathological profile of hepatoblastoma: An experience from a tertiary care center in India |
| title_full_unstemmed | Clinicopathological profile of hepatoblastoma: An experience from a tertiary care center in India |
| title_short | Clinicopathological profile of hepatoblastoma: An experience from a tertiary care center in India |
| title_sort | clinicopathological profile of hepatoblastoma an experience from a tertiary care center in india |
| topic | Alpha fetoprotein hepatoblastoma histology PRETEXT |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2019;volume=62;issue=4;spage=556;epage=560;aulast=Archana |
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