Immunohistochemical prognostic factors, qualifying constructs and determinant adverse events in overall survival in invasive breast carcinomas
Immunohistochemical prognosis factors or moleculars and qualifying constructs were evaluated for the contribution to overall survival, and adverse events. It was defined a nonrandom sample of 373 women with invasive breast carcinomas operated on a 15-year period (1992-2007). Results: From the evalu...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Spanish |
| Published: |
Editorial Ciencias Médicas
2014-09-01
|
| Series: | Acta Médica del Centro |
| Subjects: | |
| Online Access: | http://www.revactamedicacentro.sld.cu/index.php/amc/article/view/145 |
| _version_ | 1811193787489189888 |
|---|---|
| author | Lissette Ruiz Jorge Milagros Alegret Rodríguez Antonio Llombart-Bosh Isidro Machado Puerto Johamel Ramos Valdez |
| author_facet | Lissette Ruiz Jorge Milagros Alegret Rodríguez Antonio Llombart-Bosh Isidro Machado Puerto Johamel Ramos Valdez |
| author_sort | Lissette Ruiz Jorge |
| collection | DOAJ |
| description | Immunohistochemical prognosis factors or moleculars and qualifying constructs were evaluated for the contribution to overall survival, and adverse events. It was defined a nonrandom sample of 373 women with invasive breast carcinomas operated on a 15-year period (1992-2007). Results: From the evaluated factors the most contributed to overall survival were the p53 with seven patients (three deaths and 57.1% survival to the value 2 +) and 20 cases (five deaths and 75.0% overall survival for the value 3 +); the Bcl2 gene with 47 patients -13 died and 72.3% survival rate for the zero value and 40 cases (five deaths and 87.5% survival rate for the value 1 +); Top Nottingham prognostic index of 5.4 with 91 patients Nottingham greater forecasting 5.4 with 91 patients -38 died, 69.7% overall survival and an average of 9.33 years, stage IV according to the classification TNMp with a female patient -who died, with an average of 1.49 years, followe by the stage IIIC with 31 patients -21 of them dead, 32.3% survival and an average of 4.68 years, the N3 component with 32 patients -22 died, 31.3% overall survival and an average of 4.58 years; the M1component with a female patient -who died, with an average of 1.49 years, local recurrence with 17 patients –nine of them died, 47.1% survival and an average of 9.57 years, and distant metastases with 51 patients - 59 dead, with an overall survival of 13.6% and an average of 5.16 years. Conclusion: p53 positive values and negative of Bcl-2, the largest group prognosis of 5.4, stages IV and III C, N3 and M1 components, local recurrence and distant metastases were most influenced in overall survival. |
| first_indexed | 2024-04-12T00:15:16Z |
| format | Article |
| id | doaj.art-c520c5a28ef5482a958bf8b772015304 |
| institution | Directory Open Access Journal |
| issn | 2709-7927 |
| language | Spanish |
| last_indexed | 2024-04-12T00:15:16Z |
| publishDate | 2014-09-01 |
| publisher | Editorial Ciencias Médicas |
| record_format | Article |
| series | Acta Médica del Centro |
| spelling | doaj.art-c520c5a28ef5482a958bf8b7720153042022-12-22T03:55:52ZspaEditorial Ciencias MédicasActa Médica del Centro2709-79272014-09-01834856134Immunohistochemical prognostic factors, qualifying constructs and determinant adverse events in overall survival in invasive breast carcinomasLissette Ruiz Jorge0Milagros Alegret Rodríguez1Antonio Llombart-Bosh2Isidro Machado Puerto3Johamel Ramos Valdez4Hospital Clínico Quirúrgico “Arnaldo Milián Castro”, Villa ClaraCentro Provincial de Higiene y Epidemiología, Santa Clara, Villa ClaraUniversidad de ValenciaInstituto Valenciano de Oncología, ValenciaHospital Clínico Quirúrgico “Arnaldo Milián Castro”, Santa Clara, Villa ClaraImmunohistochemical prognosis factors or moleculars and qualifying constructs were evaluated for the contribution to overall survival, and adverse events. It was defined a nonrandom sample of 373 women with invasive breast carcinomas operated on a 15-year period (1992-2007). Results: From the evaluated factors the most contributed to overall survival were the p53 with seven patients (three deaths and 57.1% survival to the value 2 +) and 20 cases (five deaths and 75.0% overall survival for the value 3 +); the Bcl2 gene with 47 patients -13 died and 72.3% survival rate for the zero value and 40 cases (five deaths and 87.5% survival rate for the value 1 +); Top Nottingham prognostic index of 5.4 with 91 patients Nottingham greater forecasting 5.4 with 91 patients -38 died, 69.7% overall survival and an average of 9.33 years, stage IV according to the classification TNMp with a female patient -who died, with an average of 1.49 years, followe by the stage IIIC with 31 patients -21 of them dead, 32.3% survival and an average of 4.68 years, the N3 component with 32 patients -22 died, 31.3% overall survival and an average of 4.58 years; the M1component with a female patient -who died, with an average of 1.49 years, local recurrence with 17 patients –nine of them died, 47.1% survival and an average of 9.57 years, and distant metastases with 51 patients - 59 dead, with an overall survival of 13.6% and an average of 5.16 years. Conclusion: p53 positive values and negative of Bcl-2, the largest group prognosis of 5.4, stages IV and III C, N3 and M1 components, local recurrence and distant metastases were most influenced in overall survival.http://www.revactamedicacentro.sld.cu/index.php/amc/article/view/145neoplasias de la mamapronósticoanálisis de supervivencia |
| spellingShingle | Lissette Ruiz Jorge Milagros Alegret Rodríguez Antonio Llombart-Bosh Isidro Machado Puerto Johamel Ramos Valdez Immunohistochemical prognostic factors, qualifying constructs and determinant adverse events in overall survival in invasive breast carcinomas Acta Médica del Centro neoplasias de la mama pronóstico análisis de supervivencia |
| title | Immunohistochemical prognostic factors, qualifying constructs and determinant adverse events in overall survival in invasive breast carcinomas |
| title_full | Immunohistochemical prognostic factors, qualifying constructs and determinant adverse events in overall survival in invasive breast carcinomas |
| title_fullStr | Immunohistochemical prognostic factors, qualifying constructs and determinant adverse events in overall survival in invasive breast carcinomas |
| title_full_unstemmed | Immunohistochemical prognostic factors, qualifying constructs and determinant adverse events in overall survival in invasive breast carcinomas |
| title_short | Immunohistochemical prognostic factors, qualifying constructs and determinant adverse events in overall survival in invasive breast carcinomas |
| title_sort | immunohistochemical prognostic factors qualifying constructs and determinant adverse events in overall survival in invasive breast carcinomas |
| topic | neoplasias de la mama pronóstico análisis de supervivencia |
| url | http://www.revactamedicacentro.sld.cu/index.php/amc/article/view/145 |
| work_keys_str_mv | AT lissetteruizjorge immunohistochemicalprognosticfactorsqualifyingconstructsanddeterminantadverseeventsinoverallsurvivalininvasivebreastcarcinomas AT milagrosalegretrodriguez immunohistochemicalprognosticfactorsqualifyingconstructsanddeterminantadverseeventsinoverallsurvivalininvasivebreastcarcinomas AT antoniollombartbosh immunohistochemicalprognosticfactorsqualifyingconstructsanddeterminantadverseeventsinoverallsurvivalininvasivebreastcarcinomas AT isidromachadopuerto immunohistochemicalprognosticfactorsqualifyingconstructsanddeterminantadverseeventsinoverallsurvivalininvasivebreastcarcinomas AT johamelramosvaldez immunohistochemicalprognosticfactorsqualifyingconstructsanddeterminantadverseeventsinoverallsurvivalininvasivebreastcarcinomas |