Genetic Stability of Driver Alterations in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type and Their Relapses: A Rationale for the Use of Molecular-Based Methods for More Effective Disease Monitoring

Genetic Stability of Driver Alterations in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type and Their Relapses: A Rationale for the Use of Molecular-Based Methods for More Effective Disease Monitoring

Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) is a rare, aggressive cutaneous lymphoma with a 5-year disease-specific survival of only ~55%. Despite high response rates to initial immune-polychemotherapy, most patients experience a disease relapse. The genetic evolution of p...

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Bibliographic Details
Main Authors: Anne M. R. Schrader, Ruben A. L. de Groen, Rein Willemze, Patty M. Jansen, Koen D. Quint, Arjen H. G. Cleven, Tom van Wezel, Ronald van Eijk, Dina Ruano, J. Hendrik Veelken, Cornelis P. Tensen, Karen J. Neelis, Laurien A. Daniels, Esther Hauben, F. J. Sherida H. Woei-A-Jin, Anne-Marie Busschots, Maarten H. Vermeer, Joost S. P. Vermaat
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
primary cutaneous diffuse large B-cell lymphoma
leg type
genetic stability
survival
targeted therapies
liquid biopsies
Online Access:https://www.mdpi.com/2072-6694/14/20/5152

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