Susceptibility pattern of multi-drug resistance Pseudomonas aeruginosa isolates from tertiary care hospital in Riyadh, KSA
Objectives: Pseudomonas aeruginosa is important pathogens commonly cause nosocomial infections. The occurrence of multi-resistant organisms (MROs) of Pseudomonas aeruginosa strains have been increased worldwide and limiting the therapeutic options. The MRO of Pseudomonas aeruginosa phenotype can be...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Journal of King Saud University: Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1018364723001647 |
| _version_ | 1797804692135215104 |
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| author | Hanan O. Alshammari Ali Somily Malak Yahia Qattan Roua A. Alsubki Ihab M. Moussa |
| author_facet | Hanan O. Alshammari Ali Somily Malak Yahia Qattan Roua A. Alsubki Ihab M. Moussa |
| author_sort | Hanan O. Alshammari |
| collection | DOAJ |
| description | Objectives: Pseudomonas aeruginosa is important pathogens commonly cause nosocomial infections. The occurrence of multi-resistant organisms (MROs) of Pseudomonas aeruginosa strains have been increased worldwide and limiting the therapeutic options. The MRO of Pseudomonas aeruginosa phenotype can be mediated by a variety of resistance mechanisms and highly versatile property to mutate. Therefore the our study aimed to evaluate the resistance pattern of Pseudomonas aeruginosa collected from Riyadh tertiary care hospital, Kingdom of Saudi Arabia. Methods: During the period from 2019 to 2021 clinical samples were collected from microbiology lab at King Khalid University Hospital and analysed for the antibiotic susceptibility pattern. Results: Suggested that the rates of resistance for the three years were higher for isolates collected from patients older than 50 years if its compared with the strains collected from young age. A total of 1024 Pseudomonas aeruginosa isolates were collected during the last three years, the prevalence rate were 44.6%, 32.6% and 22.7% during the period of 2019, 2020, and 2021 respectively. Meanwhile, the highest percentages of multi drug resistance Pseudomonas aeruginosa strains were recovered from body fluids; about 38 (47.5%) out of 80 Pseudomonas aeruginosa isolates were MRO Pseudomonas aeruginosa. The rate of resistances showed that Imipenem was significantly higher in resistant among the clinical isolates (77.8%), then Meropenem (61%), Aztreonam (42%) and Ceftazidime (36%) than other antibiotics. Most of isolates were sensitive to colistin except (2.7%) were resistance. Moreover, antibiotic resistant bacteria have been observed with increasing frequency over the past three years. Conclusions: The current study reports that the susceptibility among P. aeruginosa isolates have been decreased in KSA, perhaps due to the massive use of antibiotics, the lack of adherence to approved infection control practices by hospitals, or due to the changes to the public health infrastructure. |
| first_indexed | 2024-03-13T05:39:54Z |
| format | Article |
| id | doaj.art-c52659d4dd784fb0920c9e7af6b29b70 |
| institution | Directory Open Access Journal |
| issn | 1018-3647 |
| language | English |
| last_indexed | 2024-03-13T05:39:54Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of King Saud University: Science |
| spelling | doaj.art-c52659d4dd784fb0920c9e7af6b29b702023-06-14T04:32:52ZengElsevierJournal of King Saud University: Science1018-36472023-07-01355102702Susceptibility pattern of multi-drug resistance Pseudomonas aeruginosa isolates from tertiary care hospital in Riyadh, KSAHanan O. Alshammari0Ali Somily1Malak Yahia Qattan2Roua A. Alsubki3Ihab M. Moussa4Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of pathology and microbiology, College of Medicine, King Saud University, Saudi ArabiaDepartment of Health Science College of Applied Medical Science and Community, King Saud University, P.O. Box 22542, Riyadh 11495, Saudi ArabiaDepartment of Clinical Laboratory Science, College of Applied Medical Science, King Saud University, Saudi ArabiaDepartment of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia; Corresponding author at: Department of Botany and Microbiology, College of Science, King Saud University, P. O. Box 2455, Riyadh, Saudi Arabia.Objectives: Pseudomonas aeruginosa is important pathogens commonly cause nosocomial infections. The occurrence of multi-resistant organisms (MROs) of Pseudomonas aeruginosa strains have been increased worldwide and limiting the therapeutic options. The MRO of Pseudomonas aeruginosa phenotype can be mediated by a variety of resistance mechanisms and highly versatile property to mutate. Therefore the our study aimed to evaluate the resistance pattern of Pseudomonas aeruginosa collected from Riyadh tertiary care hospital, Kingdom of Saudi Arabia. Methods: During the period from 2019 to 2021 clinical samples were collected from microbiology lab at King Khalid University Hospital and analysed for the antibiotic susceptibility pattern. Results: Suggested that the rates of resistance for the three years were higher for isolates collected from patients older than 50 years if its compared with the strains collected from young age. A total of 1024 Pseudomonas aeruginosa isolates were collected during the last three years, the prevalence rate were 44.6%, 32.6% and 22.7% during the period of 2019, 2020, and 2021 respectively. Meanwhile, the highest percentages of multi drug resistance Pseudomonas aeruginosa strains were recovered from body fluids; about 38 (47.5%) out of 80 Pseudomonas aeruginosa isolates were MRO Pseudomonas aeruginosa. The rate of resistances showed that Imipenem was significantly higher in resistant among the clinical isolates (77.8%), then Meropenem (61%), Aztreonam (42%) and Ceftazidime (36%) than other antibiotics. Most of isolates were sensitive to colistin except (2.7%) were resistance. Moreover, antibiotic resistant bacteria have been observed with increasing frequency over the past three years. Conclusions: The current study reports that the susceptibility among P. aeruginosa isolates have been decreased in KSA, perhaps due to the massive use of antibiotics, the lack of adherence to approved infection control practices by hospitals, or due to the changes to the public health infrastructure.http://www.sciencedirect.com/science/article/pii/S1018364723001647Pseudomonas aeruginosaAntibiotic susceptibilityClinical isolatesMulti-drug resistant |
| spellingShingle | Hanan O. Alshammari Ali Somily Malak Yahia Qattan Roua A. Alsubki Ihab M. Moussa Susceptibility pattern of multi-drug resistance Pseudomonas aeruginosa isolates from tertiary care hospital in Riyadh, KSA Journal of King Saud University: Science Pseudomonas aeruginosa Antibiotic susceptibility Clinical isolates Multi-drug resistant |
| title | Susceptibility pattern of multi-drug resistance Pseudomonas aeruginosa isolates from tertiary care hospital in Riyadh, KSA |
| title_full | Susceptibility pattern of multi-drug resistance Pseudomonas aeruginosa isolates from tertiary care hospital in Riyadh, KSA |
| title_fullStr | Susceptibility pattern of multi-drug resistance Pseudomonas aeruginosa isolates from tertiary care hospital in Riyadh, KSA |
| title_full_unstemmed | Susceptibility pattern of multi-drug resistance Pseudomonas aeruginosa isolates from tertiary care hospital in Riyadh, KSA |
| title_short | Susceptibility pattern of multi-drug resistance Pseudomonas aeruginosa isolates from tertiary care hospital in Riyadh, KSA |
| title_sort | susceptibility pattern of multi drug resistance pseudomonas aeruginosa isolates from tertiary care hospital in riyadh ksa |
| topic | Pseudomonas aeruginosa Antibiotic susceptibility Clinical isolates Multi-drug resistant |
| url | http://www.sciencedirect.com/science/article/pii/S1018364723001647 |
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