Segmental strain for scar detection in acute myocardial infarcts and in follow-up exams using non-contrast CMR cine sequences
Abstract Background The purpose of the study was to investigate feasibility of infarct detection in segmental strain derived from non-contrast cardiac magnetic resonance (CMR) cine sequences in patients with acute myocardial infarction (AMI) and in follow-up (FU) exams. Methods 57 patients with AMI...
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-022-02664-z |
| _version_ | 1811341398328213504 |
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| author | Malgorzata Polacin Mihaly Karolyi Matthias Eberhard Ioannis Matziris Hatem Alkadhi Sebastian Kozerke Robert Manka |
| author_facet | Malgorzata Polacin Mihaly Karolyi Matthias Eberhard Ioannis Matziris Hatem Alkadhi Sebastian Kozerke Robert Manka |
| author_sort | Malgorzata Polacin |
| collection | DOAJ |
| description | Abstract Background The purpose of the study was to investigate feasibility of infarct detection in segmental strain derived from non-contrast cardiac magnetic resonance (CMR) cine sequences in patients with acute myocardial infarction (AMI) and in follow-up (FU) exams. Methods 57 patients with AMI (mean age 61 ± 12 years, CMR 2.8 ± 2 days after infarction) were retrospectively included, FU exams were available in 32 patients (35 ± 14 days after first CMR). 43 patients with normal CMR (54 ± 11 years) served as controls. Dedicated software (Segment CMR, Medviso) was used to calculate global and segmental strain derived from cine sequences. Cine short axis stacks and segmental circumferential strain calculations of every patient and control were presented to two blinded readers in random order, who were advised to identify potentially infarcted segments, blinded to LGE and clinical information. Results Impaired global strain was measured in AMI patients compared to controls (global peak circumferential strain [GPCS] p = 0.01; global peak longitudinal strain [GPLS] p = 0.04; global peak radial strain [GPRS] p = 0.01). In both imaging time points, mean segmental peak circumferential strain [SPCS] was impaired in infarcted tissue compared to remote segments (AMI: p = 0.03, FU: p = 0.02). SPCS values in infarcted segments were similar between AMI and FU (p = 0.8). In SPCS calculations, 141 from 189 acutely infarcted segments were accurately detected (74.6%), visual evaluation of correlating cine images detected 43.4% infarcts. In FU, 80% infarcted segments (91/114 segments) were detected in SPCS and 51.8% by visual evaluation of correlating short axis cine images (p = 0.01). Conclusion Segmental circumferential strain derived from routinely acquired native cine sequences detects nearly 75% of acute infarcts and 80% of infarcts in subacute follow-up CMR, significantly more than visual evaluation of correlating cine images alone. Acute infarcts may display only subtle impairment of wall motion and no obvious wall thinning, thus SPCS calculation might be helpful for scar detection in patients with acute infarcts, when LGE images are not available. |
| first_indexed | 2024-04-13T18:54:51Z |
| format | Article |
| id | doaj.art-c526cebaa819496f8b55e8c76e4f9688 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-13T18:54:51Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-c526cebaa819496f8b55e8c76e4f96882022-12-22T02:34:17ZengBMCBMC Cardiovascular Disorders1471-22612022-05-0122111110.1186/s12872-022-02664-zSegmental strain for scar detection in acute myocardial infarcts and in follow-up exams using non-contrast CMR cine sequencesMalgorzata Polacin0Mihaly Karolyi1Matthias Eberhard2Ioannis Matziris3Hatem Alkadhi4Sebastian Kozerke5Robert Manka6Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of ZurichInstitute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of ZurichInstitute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of ZurichDepartment of Cardiology, University Heart Center, University Hospital Zurich, University of ZurichInstitute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of ZurichInstitute for Biomedical Engineering, University and ETH ZurichInstitute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of ZurichAbstract Background The purpose of the study was to investigate feasibility of infarct detection in segmental strain derived from non-contrast cardiac magnetic resonance (CMR) cine sequences in patients with acute myocardial infarction (AMI) and in follow-up (FU) exams. Methods 57 patients with AMI (mean age 61 ± 12 years, CMR 2.8 ± 2 days after infarction) were retrospectively included, FU exams were available in 32 patients (35 ± 14 days after first CMR). 43 patients with normal CMR (54 ± 11 years) served as controls. Dedicated software (Segment CMR, Medviso) was used to calculate global and segmental strain derived from cine sequences. Cine short axis stacks and segmental circumferential strain calculations of every patient and control were presented to two blinded readers in random order, who were advised to identify potentially infarcted segments, blinded to LGE and clinical information. Results Impaired global strain was measured in AMI patients compared to controls (global peak circumferential strain [GPCS] p = 0.01; global peak longitudinal strain [GPLS] p = 0.04; global peak radial strain [GPRS] p = 0.01). In both imaging time points, mean segmental peak circumferential strain [SPCS] was impaired in infarcted tissue compared to remote segments (AMI: p = 0.03, FU: p = 0.02). SPCS values in infarcted segments were similar between AMI and FU (p = 0.8). In SPCS calculations, 141 from 189 acutely infarcted segments were accurately detected (74.6%), visual evaluation of correlating cine images detected 43.4% infarcts. In FU, 80% infarcted segments (91/114 segments) were detected in SPCS and 51.8% by visual evaluation of correlating short axis cine images (p = 0.01). Conclusion Segmental circumferential strain derived from routinely acquired native cine sequences detects nearly 75% of acute infarcts and 80% of infarcts in subacute follow-up CMR, significantly more than visual evaluation of correlating cine images alone. Acute infarcts may display only subtle impairment of wall motion and no obvious wall thinning, thus SPCS calculation might be helpful for scar detection in patients with acute infarcts, when LGE images are not available.https://doi.org/10.1186/s12872-022-02664-zCardiac magnetic resonanceAcute myocardial infarctionIschemic heart diseaseFeature tracking |
| spellingShingle | Malgorzata Polacin Mihaly Karolyi Matthias Eberhard Ioannis Matziris Hatem Alkadhi Sebastian Kozerke Robert Manka Segmental strain for scar detection in acute myocardial infarcts and in follow-up exams using non-contrast CMR cine sequences BMC Cardiovascular Disorders Cardiac magnetic resonance Acute myocardial infarction Ischemic heart disease Feature tracking |
| title | Segmental strain for scar detection in acute myocardial infarcts and in follow-up exams using non-contrast CMR cine sequences |
| title_full | Segmental strain for scar detection in acute myocardial infarcts and in follow-up exams using non-contrast CMR cine sequences |
| title_fullStr | Segmental strain for scar detection in acute myocardial infarcts and in follow-up exams using non-contrast CMR cine sequences |
| title_full_unstemmed | Segmental strain for scar detection in acute myocardial infarcts and in follow-up exams using non-contrast CMR cine sequences |
| title_short | Segmental strain for scar detection in acute myocardial infarcts and in follow-up exams using non-contrast CMR cine sequences |
| title_sort | segmental strain for scar detection in acute myocardial infarcts and in follow up exams using non contrast cmr cine sequences |
| topic | Cardiac magnetic resonance Acute myocardial infarction Ischemic heart disease Feature tracking |
| url | https://doi.org/10.1186/s12872-022-02664-z |
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