Pandemic influenza A/H1N1 (sw2009) in Russia: epidemiology, diagnosis, clinical picture, and treatment
Aim. To study the epidemiological and clinical features of the 2009-2010 pandemic influenza in Russia. Subjects and methods. Materials from 874 patients, including postmortem samples from 287 subjects, were examined applying the AmpliSens Influenza virus A/H1-swine-FL PCR kit designed and produced b...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2010-11-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/30689 |
| _version_ | 1818134631994621952 |
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| author | Svetlana Borisovna Yatsyshina Andrey Nikolaevich Minenko Tat'yanaya Evgen'evna Kushakova Mariya Nikolaevna Praded Anna Viktorovna Kudryavtseva German Aleksandrovich Shipulin Viktor Vasil'evich Maleev V I Pokrovskiy S B Yatsyshina A N Minenko T E Kushakova M N Praded A V Kudryavtseva G A Shipulin V V Maleyev V I Pokrovsky |
| author_facet | Svetlana Borisovna Yatsyshina Andrey Nikolaevich Minenko Tat'yanaya Evgen'evna Kushakova Mariya Nikolaevna Praded Anna Viktorovna Kudryavtseva German Aleksandrovich Shipulin Viktor Vasil'evich Maleev V I Pokrovskiy S B Yatsyshina A N Minenko T E Kushakova M N Praded A V Kudryavtseva G A Shipulin V V Maleyev V I Pokrovsky |
| author_sort | Svetlana Borisovna Yatsyshina |
| collection | DOAJ |
| description | Aim. To study the epidemiological and clinical features of the 2009-2010 pandemic influenza in Russia.
Subjects and methods. Materials from 874 patients, including postmortem samples from 287 subjects, were examined applying the AmpliSens Influenza virus A/H1-swine-FL PCR kit designed and produced by the Central Research Institute of Epidemiology. The clinical and postmortem characteristics of 68 patients who had died from influenza A/H1N1 (sw2009) were analyzed in detail.
Results. The cause of deaths was primary virus pneumonia in most cases. The major manifestation of viral pathogenicity was impaired microcirculation leading to hemorrhage. No mutations conferring resistance to oseltamivir and arbidol were found. All A/H1N1swl viruses had genetic markers of remantadin resistance.
Conclusion. The reagent kits developed by the Central Research Institute of Epidemiology proved to be effective. It is necessary to set up PCR laboratories that differentially diagnose influenza and acute respiratory viral infections in health care facilities in order to make early laboratory diagnosis of influenza and to timely perform its specific therapy. |
| first_indexed | 2024-12-11T09:11:42Z |
| format | Article |
| id | doaj.art-c5276fcd23244a52b67781dc751f83e3 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-11T09:11:42Z |
| publishDate | 2010-11-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-c5276fcd23244a52b67781dc751f83e32022-12-22T01:13:29Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422010-11-018211101427716Pandemic influenza A/H1N1 (sw2009) in Russia: epidemiology, diagnosis, clinical picture, and treatmentSvetlana Borisovna YatsyshinaAndrey Nikolaevich MinenkoTat'yanaya Evgen'evna KushakovaMariya Nikolaevna PradedAnna Viktorovna KudryavtsevaGerman Aleksandrovich ShipulinViktor Vasil'evich MaleevV I PokrovskiyS B Yatsyshina0A N Minenko1T E Kushakova2M N Praded3A V Kudryavtseva4G A Shipulin5V V Maleyev6V I Pokrovsky7Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human WelfareCentral Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human WelfareCentral Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human WelfareCentral Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human WelfareCentral Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human WelfareCentral Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human WelfareCentral Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human WelfareCentral Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human WelfareAim. To study the epidemiological and clinical features of the 2009-2010 pandemic influenza in Russia. Subjects and methods. Materials from 874 patients, including postmortem samples from 287 subjects, were examined applying the AmpliSens Influenza virus A/H1-swine-FL PCR kit designed and produced by the Central Research Institute of Epidemiology. The clinical and postmortem characteristics of 68 patients who had died from influenza A/H1N1 (sw2009) were analyzed in detail. Results. The cause of deaths was primary virus pneumonia in most cases. The major manifestation of viral pathogenicity was impaired microcirculation leading to hemorrhage. No mutations conferring resistance to oseltamivir and arbidol were found. All A/H1N1swl viruses had genetic markers of remantadin resistance. Conclusion. The reagent kits developed by the Central Research Institute of Epidemiology proved to be effective. It is necessary to set up PCR laboratories that differentially diagnose influenza and acute respiratory viral infections in health care facilities in order to make early laboratory diagnosis of influenza and to timely perform its specific therapy.https://ter-arkhiv.ru/0040-3660/article/view/30689pandemic influenza a/h1n1swlpcr diagnosis of influenzaclinical and postmortem features of pandemic influenza |
| spellingShingle | Svetlana Borisovna Yatsyshina Andrey Nikolaevich Minenko Tat'yanaya Evgen'evna Kushakova Mariya Nikolaevna Praded Anna Viktorovna Kudryavtseva German Aleksandrovich Shipulin Viktor Vasil'evich Maleev V I Pokrovskiy S B Yatsyshina A N Minenko T E Kushakova M N Praded A V Kudryavtseva G A Shipulin V V Maleyev V I Pokrovsky Pandemic influenza A/H1N1 (sw2009) in Russia: epidemiology, diagnosis, clinical picture, and treatment Терапевтический архив pandemic influenza a/h1n1swl pcr diagnosis of influenza clinical and postmortem features of pandemic influenza |
| title | Pandemic influenza A/H1N1 (sw2009) in Russia: epidemiology, diagnosis, clinical picture, and treatment |
| title_full | Pandemic influenza A/H1N1 (sw2009) in Russia: epidemiology, diagnosis, clinical picture, and treatment |
| title_fullStr | Pandemic influenza A/H1N1 (sw2009) in Russia: epidemiology, diagnosis, clinical picture, and treatment |
| title_full_unstemmed | Pandemic influenza A/H1N1 (sw2009) in Russia: epidemiology, diagnosis, clinical picture, and treatment |
| title_short | Pandemic influenza A/H1N1 (sw2009) in Russia: epidemiology, diagnosis, clinical picture, and treatment |
| title_sort | pandemic influenza a h1n1 sw2009 in russia epidemiology diagnosis clinical picture and treatment |
| topic | pandemic influenza a/h1n1swl pcr diagnosis of influenza clinical and postmortem features of pandemic influenza |
| url | https://ter-arkhiv.ru/0040-3660/article/view/30689 |
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