Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls
A comparative in vitro study of the antioxidant potential of natural phenols (zingerone, curcumin, raspberry ketone, magnolol) and their synthesized derivatives was performed. The antioxidant efficiency was evaluated in blood serum obtained from healthy individuals, by means of spectrophotometry, be...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/6/2646 |
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| author | Kristina Kostić Jasmina Brborić Giovanna Delogu Milena R. Simić Stevan Samardžić Zoran Maksimović Maria Antonietta Dettori Davide Fabbri Jelena Kotur-Stevuljević Luciano Saso |
| author_facet | Kristina Kostić Jasmina Brborić Giovanna Delogu Milena R. Simić Stevan Samardžić Zoran Maksimović Maria Antonietta Dettori Davide Fabbri Jelena Kotur-Stevuljević Luciano Saso |
| author_sort | Kristina Kostić |
| collection | DOAJ |
| description | A comparative in vitro study of the antioxidant potential of natural phenols (zingerone, curcumin, raspberry ketone, magnolol) and their synthesized derivatives was performed. The antioxidant efficiency was evaluated in blood serum obtained from healthy individuals, by means of spectrophotometry, before and after the addition of pro-oxidant <i>tert</i>-butyl hydroperoxide (TBH). Moreover, the antioxidant effect of an equimolar mixture of curcumin and zingerone was investigated. Interpretation of our results reveals that in the blood serum of healthy individuals curcumin (C1), raspberry ketone (RK1), magnolol (M1) and synthesized derivative of zingerone (Z2) demonstrate remarkable antioxidant effects (<i>p</i> < 0.05). However, in the state of TBH-induced excessive oxidative stress natural magnolol and synthesized derivatives C1, Z1 and RK1 show powerful antioxidant activity and thus can be further investigated to obtain information about their metabolic transformations and their potential influence at the cellular level. Results obtained from measurements in an equimolar mixture of zingerone and curcumin indicate synergism (<i>p</i> < 0.05) between the two compounds. This combination is especially successful due to the fast and efficient neutralization of added pro-oxidant TBH. The commercial availability of turmeric and ginger and their frequent combined use in diet suggest ideas for further broader utilization of the beneficial synergistic effect of their phenolic components. |
| first_indexed | 2024-03-11T06:07:44Z |
| format | Article |
| id | doaj.art-c527acfd9d1c4abd93980477dc321d94 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T06:07:44Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c527acfd9d1c4abd93980477dc321d942023-11-17T12:53:12ZengMDPI AGMolecules1420-30492023-03-01286264610.3390/molecules28062646Antioxidant Activity of Natural Phenols and Derived Hydroxylated BiphenylsKristina Kostić0Jasmina Brborić1Giovanna Delogu2Milena R. Simić3Stevan Samardžić4Zoran Maksimović5Maria Antonietta Dettori6Davide Fabbri7Jelena Kotur-Stevuljević8Luciano Saso9Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, SerbiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, SerbiaSassari Unit, Institute of Biomolecular Chemistry of CNR, Traversa La Crucca 3, 07100 Sassari, ItalyDepartment of Organic Chemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, SerbiaDepartment of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, SerbiaDepartment of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, SerbiaSassari Unit, Institute of Biomolecular Chemistry of CNR, Traversa La Crucca 3, 07100 Sassari, ItalySassari Unit, Institute of Biomolecular Chemistry of CNR, Traversa La Crucca 3, 07100 Sassari, ItalyDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, SerbiaDepartment of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyA comparative in vitro study of the antioxidant potential of natural phenols (zingerone, curcumin, raspberry ketone, magnolol) and their synthesized derivatives was performed. The antioxidant efficiency was evaluated in blood serum obtained from healthy individuals, by means of spectrophotometry, before and after the addition of pro-oxidant <i>tert</i>-butyl hydroperoxide (TBH). Moreover, the antioxidant effect of an equimolar mixture of curcumin and zingerone was investigated. Interpretation of our results reveals that in the blood serum of healthy individuals curcumin (C1), raspberry ketone (RK1), magnolol (M1) and synthesized derivative of zingerone (Z2) demonstrate remarkable antioxidant effects (<i>p</i> < 0.05). However, in the state of TBH-induced excessive oxidative stress natural magnolol and synthesized derivatives C1, Z1 and RK1 show powerful antioxidant activity and thus can be further investigated to obtain information about their metabolic transformations and their potential influence at the cellular level. Results obtained from measurements in an equimolar mixture of zingerone and curcumin indicate synergism (<i>p</i> < 0.05) between the two compounds. This combination is especially successful due to the fast and efficient neutralization of added pro-oxidant TBH. The commercial availability of turmeric and ginger and their frequent combined use in diet suggest ideas for further broader utilization of the beneficial synergistic effect of their phenolic components.https://www.mdpi.com/1420-3049/28/6/2646phenolic compoundsoxidative stressantioxidantsbiological matrixhuman serum |
| spellingShingle | Kristina Kostić Jasmina Brborić Giovanna Delogu Milena R. Simić Stevan Samardžić Zoran Maksimović Maria Antonietta Dettori Davide Fabbri Jelena Kotur-Stevuljević Luciano Saso Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls Molecules phenolic compounds oxidative stress antioxidants biological matrix human serum |
| title | Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls |
| title_full | Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls |
| title_fullStr | Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls |
| title_full_unstemmed | Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls |
| title_short | Antioxidant Activity of Natural Phenols and Derived Hydroxylated Biphenyls |
| title_sort | antioxidant activity of natural phenols and derived hydroxylated biphenyls |
| topic | phenolic compounds oxidative stress antioxidants biological matrix human serum |
| url | https://www.mdpi.com/1420-3049/28/6/2646 |
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