The aged brain: genesis and fate of residual progenitor cells in the subventricular zone
Neural stem cells persist in the adult mammalian brain through life. The subventricular zone is the largest source of stem cells in the nervous system, and continuously generates new neuronal and glial cells involved in brain regeneration. During aging, the germinal potential of the subventricular z...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-09-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00365/full |
| _version_ | 1811269332027572224 |
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| author | Vivian eCapilla-Gonzalez Vivian eCapilla-Gonzalez Vicente eHerranz-Pérez Vicente eHerranz-Pérez Jose Manuel eGarcía-Verdugo Jose Manuel eGarcía-Verdugo |
| author_facet | Vivian eCapilla-Gonzalez Vivian eCapilla-Gonzalez Vicente eHerranz-Pérez Vicente eHerranz-Pérez Jose Manuel eGarcía-Verdugo Jose Manuel eGarcía-Verdugo |
| author_sort | Vivian eCapilla-Gonzalez |
| collection | DOAJ |
| description | Neural stem cells persist in the adult mammalian brain through life. The subventricular zone is the largest source of stem cells in the nervous system, and continuously generates new neuronal and glial cells involved in brain regeneration. During aging, the germinal potential of the subventricular zone suffers a widespread decline, but the causes of this turn down are not fully understood. This review provides a compilation of the current knowledge about the age-related changes in the neural stem cell population, as well as the fate of the newly generated cells in the aged brain. It is known that the neurogenic capacity is clearly disrupted during aging, while the production of oligodendroglial cells is not compromised. Interestingly, the human brain seems to primarily preserve the ability to produce new oligodendrocytes instead of neurons, which could be related to the development of neurological disorders. Further studies in this matter are required to improve our understanding and the current strategies for fighting neurological diseases associated with senescence. |
| first_indexed | 2024-04-12T21:40:12Z |
| format | Article |
| id | doaj.art-c52bad6c28fe4835b119fd43739ce9a9 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-12T21:40:12Z |
| publishDate | 2015-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-c52bad6c28fe4835b119fd43739ce9a92022-12-22T03:15:47ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022015-09-01910.3389/fncel.2015.00365159151The aged brain: genesis and fate of residual progenitor cells in the subventricular zoneVivian eCapilla-Gonzalez0Vivian eCapilla-Gonzalez1Vicente eHerranz-Pérez2Vicente eHerranz-Pérez3Jose Manuel eGarcía-Verdugo4Jose Manuel eGarcía-Verdugo5University of ValenciaAndalusian Center for Molecular Biology and Regenerative MedicineUniversity of ValenciaIIS Hospital La FeUniversity of ValenciaIIS Hospital La FeNeural stem cells persist in the adult mammalian brain through life. The subventricular zone is the largest source of stem cells in the nervous system, and continuously generates new neuronal and glial cells involved in brain regeneration. During aging, the germinal potential of the subventricular zone suffers a widespread decline, but the causes of this turn down are not fully understood. This review provides a compilation of the current knowledge about the age-related changes in the neural stem cell population, as well as the fate of the newly generated cells in the aged brain. It is known that the neurogenic capacity is clearly disrupted during aging, while the production of oligodendroglial cells is not compromised. Interestingly, the human brain seems to primarily preserve the ability to produce new oligodendrocytes instead of neurons, which could be related to the development of neurological disorders. Further studies in this matter are required to improve our understanding and the current strategies for fighting neurological diseases associated with senescence.http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00365/fullAgingNeurogenesiscell migrationRostral migratory streamoligodendrogenesissubventricular zone (SVZ) |
| spellingShingle | Vivian eCapilla-Gonzalez Vivian eCapilla-Gonzalez Vicente eHerranz-Pérez Vicente eHerranz-Pérez Jose Manuel eGarcía-Verdugo Jose Manuel eGarcía-Verdugo The aged brain: genesis and fate of residual progenitor cells in the subventricular zone Frontiers in Cellular Neuroscience Aging Neurogenesis cell migration Rostral migratory stream oligodendrogenesis subventricular zone (SVZ) |
| title | The aged brain: genesis and fate of residual progenitor cells in the subventricular zone |
| title_full | The aged brain: genesis and fate of residual progenitor cells in the subventricular zone |
| title_fullStr | The aged brain: genesis and fate of residual progenitor cells in the subventricular zone |
| title_full_unstemmed | The aged brain: genesis and fate of residual progenitor cells in the subventricular zone |
| title_short | The aged brain: genesis and fate of residual progenitor cells in the subventricular zone |
| title_sort | aged brain genesis and fate of residual progenitor cells in the subventricular zone |
| topic | Aging Neurogenesis cell migration Rostral migratory stream oligodendrogenesis subventricular zone (SVZ) |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00365/full |
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