Regulation of P-glycoprotein and Breast Cancer Resistance Protein Expression Induced by Focused Ultrasound-Mediated Blood-Brain Barrier Disruption: A Pilot Study

Regulation of P-glycoprotein and Breast Cancer Resistance Protein Expression Induced by Focused Ultrasound-Mediated Blood-Brain Barrier Disruption: A Pilot Study

The blood-brain barrier (BBB) controls brain homeostasis; it is formed by vascular endothelial cells that are physically connected by tight junctions (TJs). The BBB expresses efflux transporters such as P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), which limit the passage of sub...

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Bibliographic Details
Main Authors: Allegra Conti, Francoise Geffroy, Hermes A. S. Kamimura, Anthony Novell, Nicolas Tournier, Sébastien Mériaux, Benoit Larrat
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
focused ultrasound
BBB-opening
efflux transporter
MRgFUS
drug delivery
Online Access:https://www.mdpi.com/1422-0067/23/24/15488

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