Inverse Agonistic Activity of Antihistamines and Suppression of Histamine H1 Receptor Gene Expression

Inverse Agonistic Activity of Antihistamines and Suppression of Histamine H1 Receptor Gene Expression

Histamine H1 receptor (H1R) expression influences the severity of allergy symptoms. We examined the effect of inverse agonists on H1R gene expression. Two inverse agonists (carebastine and mepyramine), but not the neutral antagonist oxatomide, decreased inositol phosphate accumulation. The inverse a...

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Bibliographic Details
Main Authors:	Hiroyuki Mizuguchi, Shohei Ono, Masashi Hattori, Hiroyuki Fukui
Format:	Article
Language:	English
Published:	Elsevier 2012-01-01
Series:	Journal of Pharmacological Sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S134786131930605X

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