Mouse Models as a Tool for Understanding Progression in Braf-Driven Thyroid Cancers
The development of next generation sequencing (NGS) has led to marked advancement of our understanding of genetic events mediating the initiation and progression of thyroid cancers. The NGS studies have confirmed the previously reported high frequency of mutually-exclusive oncogenic alterations affe...
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2019-02-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-34-11.pdf |
| _version_ | 1828910821755846656 |
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| author | Iñigo Landa Jeffrey A. Knauf |
| author_facet | Iñigo Landa Jeffrey A. Knauf |
| author_sort | Iñigo Landa |
| collection | DOAJ |
| description | The development of next generation sequencing (NGS) has led to marked advancement of our understanding of genetic events mediating the initiation and progression of thyroid cancers. The NGS studies have confirmed the previously reported high frequency of mutually-exclusive oncogenic alterations affecting BRAF and RAS proto-oncogenes in all stages of thyroid cancer. Initially identified by traditional sequencing approaches, the NGS studies also confirmed the acquisition of alterations that inactivate tumor protein p53 (TP53) and activate phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) in advanced thyroid cancers. Novel alterations, such as those in telomerase reverse transcriptase (TERT) promoter and mating-type switching/sucrose non-fermenting (SWI/SNF) complex, are also likely to promote progression of the BRAFV600E-driven thyroid cancers. A number of genetically engineered mouse models (GEMM) of BRAFV600E-driven thyroid cancer have been developed to investigate thyroid tumorigenesis mediated by oncogenic BRAF and to explore the role of genetic alterations identified in the genomic analyses of advanced thyroid cancer to promote tumor progression. This review will discuss the various GEMMs that have been developed to investigate oncogenic BRAFV600E-driven thyroid cancers. |
| first_indexed | 2024-12-13T18:51:25Z |
| format | Article |
| id | doaj.art-c5318217c3054495a5b27d3a9c56c0da |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-12-13T18:51:25Z |
| publishDate | 2019-02-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-c5318217c3054495a5b27d3a9c56c0da2022-12-21T23:34:56ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782019-02-01341112210.3803/EnM.2019.34.1.11Mouse Models as a Tool for Understanding Progression in Braf-Driven Thyroid CancersIñigo Landa0Jeffrey A. Knauf1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, .USAHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, .USAThe development of next generation sequencing (NGS) has led to marked advancement of our understanding of genetic events mediating the initiation and progression of thyroid cancers. The NGS studies have confirmed the previously reported high frequency of mutually-exclusive oncogenic alterations affecting BRAF and RAS proto-oncogenes in all stages of thyroid cancer. Initially identified by traditional sequencing approaches, the NGS studies also confirmed the acquisition of alterations that inactivate tumor protein p53 (TP53) and activate phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) in advanced thyroid cancers. Novel alterations, such as those in telomerase reverse transcriptase (TERT) promoter and mating-type switching/sucrose non-fermenting (SWI/SNF) complex, are also likely to promote progression of the BRAFV600E-driven thyroid cancers. A number of genetically engineered mouse models (GEMM) of BRAFV600E-driven thyroid cancer have been developed to investigate thyroid tumorigenesis mediated by oncogenic BRAF and to explore the role of genetic alterations identified in the genomic analyses of advanced thyroid cancer to promote tumor progression. This review will discuss the various GEMMs that have been developed to investigate oncogenic BRAFV600E-driven thyroid cancers.https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-34-11.pdfProto-oncogene proteins B-rafThyroid neoplasmsMice, transgenic |
| spellingShingle | Iñigo Landa Jeffrey A. Knauf Mouse Models as a Tool for Understanding Progression in Braf-Driven Thyroid Cancers Endocrinology and Metabolism Proto-oncogene proteins B-raf Thyroid neoplasms Mice, transgenic |
| title | Mouse Models as a Tool for Understanding Progression in Braf-Driven Thyroid Cancers |
| title_full | Mouse Models as a Tool for Understanding Progression in Braf-Driven Thyroid Cancers |
| title_fullStr | Mouse Models as a Tool for Understanding Progression in Braf-Driven Thyroid Cancers |
| title_full_unstemmed | Mouse Models as a Tool for Understanding Progression in Braf-Driven Thyroid Cancers |
| title_short | Mouse Models as a Tool for Understanding Progression in Braf-Driven Thyroid Cancers |
| title_sort | mouse models as a tool for understanding progression in braf driven thyroid cancers |
| topic | Proto-oncogene proteins B-raf Thyroid neoplasms Mice, transgenic |
| url | https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-34-11.pdf |
| work_keys_str_mv | AT inigolanda mousemodelsasatoolforunderstandingprogressioninbrafdriventhyroidcancers AT jeffreyaknauf mousemodelsasatoolforunderstandingprogressioninbrafdriventhyroidcancers |