Screening MT1-MMP Activity and Inhibition in Three-Dimensional Tumor Spheroids

Screening MT1-MMP Activity and Inhibition in Three-Dimensional Tumor Spheroids

Membrane type 1 matrix metalloproteinase (MT1-MMP) has been shown to be crucial for tumor angiogenesis, invasion, and metastasis, and thus MT1-MMP is a high priority target for potential cancer therapies. To properly evaluate MT1-MMP inhibitors, a screening protocol is desired by which enzyme activi...

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Bibliographic Details
Main Authors:	Anna M. Knapinska, Gary Drotleff, Cedric Chai, Destiny Twohill, Alexa Ernce, Dorota Tokmina-Roszyk, Isabella Grande, Michelle Rodriguez, Brad Larson, Gregg B. Fields
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Series:	Biomedicines
Subjects:	membrane type 1 matrix metalloproteinase glioblastoma spheroid cell-based high-throughput screening triple helix collagen
Online Access:	https://www.mdpi.com/2227-9059/11/2/562

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