Rap1b-loss increases neutrophil lactate dehydrogenase activity to enhance neutrophil migration and acute inflammation in vivo

Rap1b-loss increases neutrophil lactate dehydrogenase activity to enhance neutrophil migration and acute inflammation in vivo

IntroductionNeutrophils are critical for host immune defense; yet, aberrant neutrophil tissue infiltration triggers tissue damage. Neutrophils are heterogeneous functionally, and adopt ‘normal’ or ‘pathogenic’ effector function responses. Understanding neutrophil heterogeneity could provide specific...

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Bibliographic Details
Main Authors:	Chanchal Sur Chowdhury, Elizabeth Wareham, Juying Xu, Sachin Kumar, Matthew Kofron, Sribalaji Lakshmikanthan, Magdalena Chrzanowska, Marie-Dominique Filippi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Series:	Frontiers in Immunology
Subjects:	neutrophils inflammation Ldha migration vascular leakage
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1061544/full

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