Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding
Human leucocyte antigen E (HLA-E) directly engages NK cells but also presents antigen to CD8+ T cells. Here the authors show crystal structures of HLA-E in complex with peptides derived from HIV and Mycobacterium tuberculosis, and describe binding conformations, the positional impact of residues inv...
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Bibliographic Details
| Main Authors: |
Lucy C. Walters,
Karl Harlos,
Simon Brackenridge,
Daniel Rozbesky,
Jordan R. Barrett,
Vitul Jain,
Thomas S. Walter,
Chris A. O’Callaghan,
Persephone Borrow,
Mireille Toebes,
Scott G. Hansen,
Jonah B Sacha,
Shaheed Abdulhaqq,
Justin M. Greene,
Klaus Früh,
Emily Marshall,
Louis J. Picker,
E. Yvonne Jones,
Andrew J. McMichael,
Geraldine M. Gillespie |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2018-08-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-05459-z
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