Genetic liability between COVID-19 and pre-eclampsia/eclampsia: a Mendelian randomization study
ABSTRACTObjective The aim of this study was to investigate the possible causal relationship between COVID-19 and the risk of pre-eclampsia/eclampsia using a Mendelian randomized (MR) design.Methods We estimated their genetic correlations and then performed two-sample Mendelian randomization analyses...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Hypertension in Pregnancy |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/10641955.2023.2285757 |
| _version_ | 1797448621413629952 |
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| author | Yuhang Xing Zhen Wang Xiaohua Qi Qunli Xu Rui Pu |
| author_facet | Yuhang Xing Zhen Wang Xiaohua Qi Qunli Xu Rui Pu |
| author_sort | Yuhang Xing |
| collection | DOAJ |
| description | ABSTRACTObjective The aim of this study was to investigate the possible causal relationship between COVID-19 and the risk of pre-eclampsia/eclampsia using a Mendelian randomized (MR) design.Methods We estimated their genetic correlations and then performed two-sample Mendelian randomization analyses using pooled statistics from the COVID-19 susceptibility/hospitalization genome-wide association study and the pre-eclampsia/eclampsia datasets. The main analyses were performed using the inverse variance weighting method, supplemented by the weighted median method and the MR-Egger method.Results We identified a significant and positive genetic correlation between COVID-19 susceptibility and pre-eclampsia/eclampsia [OR = 1.23 (1.01–1.51), p = 0.043]. Meanwhile, hospitalization of COVID-19 was significantly associated with a higher risk of pre-eclampsia/eclampsia [OR = 1.15 (1.02–1.30), p = 0.024]. Consistently, hospitalization of COVID-19 were nominally associated with higher risk of pre-eclampsia [OR = 1.14, (1.01–1.30), p = 0.040]. The results were robust under all sensitivity analyses.Conclusion These results suggest that COVID-19 may increase the risk of pre-eclampsia/eclampsia. Future development of preventive or therapeutic interventions should emphasize this to mitigate the complications of COVID-19. [Figure: see text] |
| first_indexed | 2024-03-09T14:14:06Z |
| format | Article |
| id | doaj.art-c538d66999a64b52898c001b73322adc |
| institution | Directory Open Access Journal |
| issn | 1064-1955 1525-6065 |
| language | English |
| last_indexed | 2024-03-09T14:14:06Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hypertension in Pregnancy |
| spelling | doaj.art-c538d66999a64b52898c001b73322adc2023-11-29T05:45:30ZengTaylor & Francis GroupHypertension in Pregnancy1064-19551525-60652023-12-0142110.1080/10641955.2023.2285757Genetic liability between COVID-19 and pre-eclampsia/eclampsia: a Mendelian randomization studyYuhang Xing0Zhen Wang1Xiaohua Qi2Qunli Xu3Rui Pu4Department of Public Health Response, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, ChinaDepartment of Public Health Response, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, ChinaDepartment of Public Health Response, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, ChinaStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, ChinaStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, ChinaABSTRACTObjective The aim of this study was to investigate the possible causal relationship between COVID-19 and the risk of pre-eclampsia/eclampsia using a Mendelian randomized (MR) design.Methods We estimated their genetic correlations and then performed two-sample Mendelian randomization analyses using pooled statistics from the COVID-19 susceptibility/hospitalization genome-wide association study and the pre-eclampsia/eclampsia datasets. The main analyses were performed using the inverse variance weighting method, supplemented by the weighted median method and the MR-Egger method.Results We identified a significant and positive genetic correlation between COVID-19 susceptibility and pre-eclampsia/eclampsia [OR = 1.23 (1.01–1.51), p = 0.043]. Meanwhile, hospitalization of COVID-19 was significantly associated with a higher risk of pre-eclampsia/eclampsia [OR = 1.15 (1.02–1.30), p = 0.024]. Consistently, hospitalization of COVID-19 were nominally associated with higher risk of pre-eclampsia [OR = 1.14, (1.01–1.30), p = 0.040]. The results were robust under all sensitivity analyses.Conclusion These results suggest that COVID-19 may increase the risk of pre-eclampsia/eclampsia. Future development of preventive or therapeutic interventions should emphasize this to mitigate the complications of COVID-19. [Figure: see text]https://www.tandfonline.com/doi/10.1080/10641955.2023.2285757COVID-19eclampsiapre-eclampsiaMendelian randomizations |
| spellingShingle | Yuhang Xing Zhen Wang Xiaohua Qi Qunli Xu Rui Pu Genetic liability between COVID-19 and pre-eclampsia/eclampsia: a Mendelian randomization study Hypertension in Pregnancy COVID-19 eclampsia pre-eclampsia Mendelian randomizations |
| title | Genetic liability between COVID-19 and pre-eclampsia/eclampsia: a Mendelian randomization study |
| title_full | Genetic liability between COVID-19 and pre-eclampsia/eclampsia: a Mendelian randomization study |
| title_fullStr | Genetic liability between COVID-19 and pre-eclampsia/eclampsia: a Mendelian randomization study |
| title_full_unstemmed | Genetic liability between COVID-19 and pre-eclampsia/eclampsia: a Mendelian randomization study |
| title_short | Genetic liability between COVID-19 and pre-eclampsia/eclampsia: a Mendelian randomization study |
| title_sort | genetic liability between covid 19 and pre eclampsia eclampsia a mendelian randomization study |
| topic | COVID-19 eclampsia pre-eclampsia Mendelian randomizations |
| url | https://www.tandfonline.com/doi/10.1080/10641955.2023.2285757 |
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