Mendelian randomization analysis reveals causal relationship between obstetric-related diseases and COVID-19
Abstract Background Several observational studies demonstrated that pregnant individuals with COVID-19 had a higher risk of preeclampsia and preterm birth. We aimed to determine whether women with COVID-19 diagnosis had adverse pregnancy outcomes. Methods A two-sample Mendelian randomization (MR) an...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Virology Journal |
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| Online Access: | https://doi.org/10.1186/s12985-024-02348-4 |
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| author | Yan Fang Dajun Fang |
| author_facet | Yan Fang Dajun Fang |
| author_sort | Yan Fang |
| collection | DOAJ |
| description | Abstract Background Several observational studies demonstrated that pregnant individuals with COVID-19 had a higher risk of preeclampsia and preterm birth. We aimed to determine whether women with COVID-19 diagnosis had adverse pregnancy outcomes. Methods A two-sample Mendelian randomization (MR) analysis in this study was used to evaluate the casual relationships between COVID-19 infection and obstetric-related diseases based on genome-wide association studies (GWAS) dataset. Inverse-variance weighted (IVW), MR-Egger and MR-PRESSO were used to infer the connection and estimate the pleiotropy respectively. Results The significant connection was observed between COVID-19 and placental disorders with betaIVW of 1.57 and odds ratio (OR) of 4.81 (95% confidence interval [CI]: 1.05–22.05, p = 0.04). However, there were no associations between COVID-19 infection and gestational diabetes mellitus (GDM) (OR = 1.12; 95% CI: 0.85–1.45, p = 0.41), other disorders of amniotic fluid and membranes (OR = 0.90; 95% CI: 0.61–1.32, p = 0.59), Intrahepatic Cholestasis of Pregnancy (ICP) (OR = 1.42; 95% CI: 0.85–2.36, p = 0.18), birth weight (OR = 1.02; 95% CI: 0.99–1.05, p = 0.19), gestational hypertension (OR = 1.00; 95% CI: 1.00–1.00, p = 0.85), spontaneous miscarriages (OR = 1.00; 95% CI: 0.96–1.04, p = 0.90) and stillbirth (OR = 1.00; 95% CI: 0.98–1.01, p = 0.62). Conclusion There was no direct causal relationship between COVID-19 infection and maternal and neonatal poor outcomes. Our study could alleviate the anxiety of pregnant women under the COVID-19 pandemic conditions partly. |
| first_indexed | 2024-04-24T16:22:46Z |
| format | Article |
| id | doaj.art-c5396c9aa7204b799fd21c145401cd1c |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-04-24T16:22:46Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-c5396c9aa7204b799fd21c145401cd1c2024-03-31T11:10:32ZengBMCVirology Journal1743-422X2024-03-012111810.1186/s12985-024-02348-4Mendelian randomization analysis reveals causal relationship between obstetric-related diseases and COVID-19Yan Fang0Dajun Fang1Department of Obstetrics and Gynecology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityDepartment of Obstetrics and Gynecology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityAbstract Background Several observational studies demonstrated that pregnant individuals with COVID-19 had a higher risk of preeclampsia and preterm birth. We aimed to determine whether women with COVID-19 diagnosis had adverse pregnancy outcomes. Methods A two-sample Mendelian randomization (MR) analysis in this study was used to evaluate the casual relationships between COVID-19 infection and obstetric-related diseases based on genome-wide association studies (GWAS) dataset. Inverse-variance weighted (IVW), MR-Egger and MR-PRESSO were used to infer the connection and estimate the pleiotropy respectively. Results The significant connection was observed between COVID-19 and placental disorders with betaIVW of 1.57 and odds ratio (OR) of 4.81 (95% confidence interval [CI]: 1.05–22.05, p = 0.04). However, there were no associations between COVID-19 infection and gestational diabetes mellitus (GDM) (OR = 1.12; 95% CI: 0.85–1.45, p = 0.41), other disorders of amniotic fluid and membranes (OR = 0.90; 95% CI: 0.61–1.32, p = 0.59), Intrahepatic Cholestasis of Pregnancy (ICP) (OR = 1.42; 95% CI: 0.85–2.36, p = 0.18), birth weight (OR = 1.02; 95% CI: 0.99–1.05, p = 0.19), gestational hypertension (OR = 1.00; 95% CI: 1.00–1.00, p = 0.85), spontaneous miscarriages (OR = 1.00; 95% CI: 0.96–1.04, p = 0.90) and stillbirth (OR = 1.00; 95% CI: 0.98–1.01, p = 0.62). Conclusion There was no direct causal relationship between COVID-19 infection and maternal and neonatal poor outcomes. Our study could alleviate the anxiety of pregnant women under the COVID-19 pandemic conditions partly.https://doi.org/10.1186/s12985-024-02348-4COVID-19Obstetric-related diseasesPlacental disordersPoor outcomes |
| spellingShingle | Yan Fang Dajun Fang Mendelian randomization analysis reveals causal relationship between obstetric-related diseases and COVID-19 Virology Journal COVID-19 Obstetric-related diseases Placental disorders Poor outcomes |
| title | Mendelian randomization analysis reveals causal relationship between obstetric-related diseases and COVID-19 |
| title_full | Mendelian randomization analysis reveals causal relationship between obstetric-related diseases and COVID-19 |
| title_fullStr | Mendelian randomization analysis reveals causal relationship between obstetric-related diseases and COVID-19 |
| title_full_unstemmed | Mendelian randomization analysis reveals causal relationship between obstetric-related diseases and COVID-19 |
| title_short | Mendelian randomization analysis reveals causal relationship between obstetric-related diseases and COVID-19 |
| title_sort | mendelian randomization analysis reveals causal relationship between obstetric related diseases and covid 19 |
| topic | COVID-19 Obstetric-related diseases Placental disorders Poor outcomes |
| url | https://doi.org/10.1186/s12985-024-02348-4 |
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