| Summary: | Maintaining proper mechanical strength and tissue volume is important for bone growth at the site of a bone defect. In this study, potassium magnesium phosphate hexahydrate (KMgPO<sub>4</sub>·6H<sub>2</sub>O, MPC) was applied to gelma-methacrylate hydrogel (GelMA) to prepare GelMA/MPC composites (GMPCs). Among these, 5 GMPC showed the best performance in vivo and in vitro. These combinations significantly enhanced the mechanical strength of GelMA and regulated the degradation and absorption rate of MPC. Considerably better mechanical properties were noted in 5 GMPC compared with other concentrations. Better bioactivity and osteogenic ability were also found in 5 GMPC. Magnesium ions (Mg<sup>2+</sup>) are bioactive and proven to promote bone tissue regeneration, in which the enhancement efficiency is closely related to Mg<sup>2+</sup> concentrations. These findings indicated that GMPCs that can release Mg<sup>2+</sup> are effective in the treatment of bone defects and hold promise for future in vivo applications.
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