Tristetraprolin promotes survival of mammary progenitor cells by restraining TNFα levels

Tristetraprolin promotes survival of mammary progenitor cells by restraining TNFα levels

Tristetraprolin (TTP) is an RNA binding protein that destabilizes mRNAs of factors involved in proliferation, invasiveness, and inflammation. Disruption of the gene that codes for TTP (Zfp36) led to severe arthritis, autoimmunity, cachexia and dermatitis in mice. It has been shown that these phenoty...

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Bibliographic Details
Main Authors: Micaela Stedile, Angela Lara Montero, Martín Emilio García Solá, María Victoria Goddio, Inés Beckerman, Emilia Bogni, Marina Ayre, Zaira Naguila, Omar A. Coso, Edith C. Kordon
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mammary gland
TTP
mammary stem/progenitor cells
MAPK-p38
TNFα
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1265475/full

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