METABOLICALLY HEALTHY OBESITY: DEFINITIONS, PROTECTIVE FACTORS, CLINICAL RELEVANCE
Obesity is a risk factor for the development of cardiovascular disease and type 2 diabetes; nevertheless, in many obese patients no cardiometabolic complications are present. For this group of patients the term “metabolically healthy obesity” (MHO) has been established in 1982. Currently, there is n...
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| Format: | Article |
| Language: | Russian |
| Published: |
MONIKI
2016-02-01
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| Series: | Alʹmanah Kliničeskoj Mediciny |
| Subjects: | |
| Online Access: | https://www.almclinmed.ru/jour/article/view/73 |
| _version_ | 1818576904199864320 |
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| author | T. I. Romantsova E. V. Ostrovskaya |
| author_facet | T. I. Romantsova E. V. Ostrovskaya |
| author_sort | T. I. Romantsova |
| collection | DOAJ |
| description | Obesity is a risk factor for the development of cardiovascular disease and type 2 diabetes; nevertheless, in many obese patients no cardiometabolic complications are present. For this group of patients the term “metabolically healthy obesity” (MHO) has been established in 1982. Currently, there is no standardized definition of MHO, and there are large variations in its prevalence rate. The underlying mechanisms of this phenotype are not clear. It has been suggested that preserved insulin sensitivity, as well as high levels of physical activity and genetic predisposition may differentiate metabolically healthy from unhealthy obese adults. Low grade inflammation in the adipose tissue is considered to be a crucial factor for the pathogenesis of metabolic diseases. Compared to the metabolically unhealthy obese phenotype, MHO is characterized by a more favorable inflammatory profile in adipose tissue, less visceral fat, less macrophagal infiltration of adipose tissue, smaller adipocyte cell size. The question remains of stability of the MHO phenotype. The aim of this review is to discuss the current literature data concerning characteristics of MHO phenotype, definitions, prevalence and potential protective mechanisms underlying MHO. We also discuss clinical implications of MHO phenotype. |
| first_indexed | 2024-12-16T06:21:25Z |
| format | Article |
| id | doaj.art-c53bb6fd70344214923f0a0e6f8d8672 |
| institution | Directory Open Access Journal |
| issn | 2072-0505 2587-9294 |
| language | Russian |
| last_indexed | 2024-12-16T06:21:25Z |
| publishDate | 2016-02-01 |
| publisher | MONIKI |
| record_format | Article |
| series | Alʹmanah Kliničeskoj Mediciny |
| spelling | doaj.art-c53bb6fd70344214923f0a0e6f8d86722022-12-21T22:41:07ZrusMONIKIAlʹmanah Kliničeskoj Mediciny2072-05052587-92942016-02-0111758610.18786/2072-0505-2015-1-75-8673METABOLICALLY HEALTHY OBESITY: DEFINITIONS, PROTECTIVE FACTORS, CLINICAL RELEVANCET. I. Romantsova0E. V. Ostrovskaya1I.M. Sechenov First Moscow State Medical UniversityI.M. Sechenov First Moscow State Medical UniversityObesity is a risk factor for the development of cardiovascular disease and type 2 diabetes; nevertheless, in many obese patients no cardiometabolic complications are present. For this group of patients the term “metabolically healthy obesity” (MHO) has been established in 1982. Currently, there is no standardized definition of MHO, and there are large variations in its prevalence rate. The underlying mechanisms of this phenotype are not clear. It has been suggested that preserved insulin sensitivity, as well as high levels of physical activity and genetic predisposition may differentiate metabolically healthy from unhealthy obese adults. Low grade inflammation in the adipose tissue is considered to be a crucial factor for the pathogenesis of metabolic diseases. Compared to the metabolically unhealthy obese phenotype, MHO is characterized by a more favorable inflammatory profile in adipose tissue, less visceral fat, less macrophagal infiltration of adipose tissue, smaller adipocyte cell size. The question remains of stability of the MHO phenotype. The aim of this review is to discuss the current literature data concerning characteristics of MHO phenotype, definitions, prevalence and potential protective mechanisms underlying MHO. We also discuss clinical implications of MHO phenotype.https://www.almclinmed.ru/jour/article/view/73metabolically healthy obesity, metabolic syndrome, insulin resistance, adipose tissue |
| spellingShingle | T. I. Romantsova E. V. Ostrovskaya METABOLICALLY HEALTHY OBESITY: DEFINITIONS, PROTECTIVE FACTORS, CLINICAL RELEVANCE Alʹmanah Kliničeskoj Mediciny metabolically healthy obesity, metabolic syndrome, insulin resistance, adipose tissue |
| title | METABOLICALLY HEALTHY OBESITY: DEFINITIONS, PROTECTIVE FACTORS, CLINICAL RELEVANCE |
| title_full | METABOLICALLY HEALTHY OBESITY: DEFINITIONS, PROTECTIVE FACTORS, CLINICAL RELEVANCE |
| title_fullStr | METABOLICALLY HEALTHY OBESITY: DEFINITIONS, PROTECTIVE FACTORS, CLINICAL RELEVANCE |
| title_full_unstemmed | METABOLICALLY HEALTHY OBESITY: DEFINITIONS, PROTECTIVE FACTORS, CLINICAL RELEVANCE |
| title_short | METABOLICALLY HEALTHY OBESITY: DEFINITIONS, PROTECTIVE FACTORS, CLINICAL RELEVANCE |
| title_sort | metabolically healthy obesity definitions protective factors clinical relevance |
| topic | metabolically healthy obesity, metabolic syndrome, insulin resistance, adipose tissue |
| url | https://www.almclinmed.ru/jour/article/view/73 |
| work_keys_str_mv | AT tiromantsova metabolicallyhealthyobesitydefinitionsprotectivefactorsclinicalrelevance AT evostrovskaya metabolicallyhealthyobesitydefinitionsprotectivefactorsclinicalrelevance |