The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions

The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions

Cell motility processes highly depend on the membrane distribution of Phosphoinositides, giving rise to cytoskeleton reshaping and membrane trafficking events. Membrane contact sites serve as platforms for direct lipid exchange and calcium fluxes between two organelles. Here, we show that VAPA, an E...

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Bibliographic Details
Main Authors: Hugo Siegfried, Georges Farkouh, Rémi Le Borgne, Catherine Pioche-Durieu, Thaïs De Azevedo Laplace, Agathe Verraes, Lucien Daunas, Jean-Marc Verbavatz, Mélina L Heuzé
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-03-01
Series:eLife
Subjects:
cell migration
membrane contact sites
cell adhesion
lipid trafficking
phosphoinositides
endoplasmic reticulum
Online Access:https://elifesciences.org/articles/85962

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