COPPER-UPTAKE IS CRITICAL FOR THE DOWN REGULATION OF SYNAPSIN AND DYNAMIN INDUCED BY NEOCUPROINE: MODULATION OF SYNAPTIC ACTIVITY IN HIPPOCAMPAL NEURONS

COPPER-UPTAKE IS CRITICAL FOR THE DOWN REGULATION OF SYNAPSIN AND DYNAMIN INDUCED BY NEOCUPROINE: MODULATION OF SYNAPTIC ACTIVITY IN HIPPOCAMPAL NEURONS

Extracellular and intracellular copper and zinc regulate synaptic activity and synaptic plasticity, which may impact brain functionality and human behavior. We have found that a metal coordinating molecule, Neocuproine, transiently increases free intracellular copper and zinc levels (i.e. min) in hi...

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Bibliographic Details
Main Authors: Patricio A Castro, Alejandra eRamirez, Fernando J Sepulveda, Christian ePeters, Humberto eFierro, Javier eWaldron, Sandra eLuza, Jorge eFuentealba, Jose F Munoz, Giancarlo V De Ferrari, Ashley Ian Bush, Luis G Aguayo, Carlos M Opazo
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Aging Neuroscience
Subjects:
Copper
Zinc
hyperexcitability
Synapsin
dynamin
neocuproine
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00319/full

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