Analysis of 5-hydroxytryptamine and its related indoles in cerebrospinal fluid of leukemic children by gas chromatography-mass spectrometry
It is meaningful to quantify some neurotransmitters in cerebrospinal fluid (CSF) for pathology and clinical diagnosis. The objective of this study was to develop a rapid and reliable method for detecting 5-hydroxyindole ethanol (5-HTOL), 5-hydroxyindole acetic acid (5-HIAA), 5-hydroxytryptophan (5-H...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2020-02-01
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| Series: | Journal of Laboratory Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/labmed-2019-0156 |
| _version_ | 1819063645177380864 |
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| author | Zhang Pingping Wang Bo Sun Yanmei Gao Jian Lian Kaoqi |
| author_facet | Zhang Pingping Wang Bo Sun Yanmei Gao Jian Lian Kaoqi |
| author_sort | Zhang Pingping |
| collection | DOAJ |
| description | It is meaningful to quantify some neurotransmitters in cerebrospinal fluid (CSF) for pathology and clinical diagnosis. The objective of this study was to develop a rapid and reliable method for detecting 5-hydroxyindole ethanol (5-HTOL), 5-hydroxyindole acetic acid (5-HIAA), 5-hydroxytryptophan (5-HTP) and 5-hydroxytryptamine (5-HT) in CSF by gas chromatography-mass spectrometry (GC-MS), and explore the clinical significance of the levels of these neurotransmitters in CSF from acute lymphoblastic leukemia (ALL). |
| first_indexed | 2024-12-21T15:17:58Z |
| format | Article |
| id | doaj.art-c53c2e342dd54e08b71e24a4bd1ae24d |
| institution | Directory Open Access Journal |
| issn | 2567-9430 2567-9449 |
| language | English |
| last_indexed | 2024-12-21T15:17:58Z |
| publishDate | 2020-02-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Journal of Laboratory Medicine |
| spelling | doaj.art-c53c2e342dd54e08b71e24a4bd1ae24d2022-12-21T18:59:06ZengDe GruyterJournal of Laboratory Medicine2567-94302567-94492020-02-01441414510.1515/labmed-2019-0156Analysis of 5-hydroxytryptamine and its related indoles in cerebrospinal fluid of leukemic children by gas chromatography-mass spectrometryZhang Pingping0Wang Bo1Sun Yanmei2Gao Jian3Lian Kaoqi4Department of Reproductive Genetic Family, Hebei General Hospital, Shijiazhuang, P.R. ChinaHandan College, Handan, P.R. ChinaDepartment of Reproductive Genetic Family, Hebei General Hospital, Shijiazhuang, P.R. ChinaDepartment of Reproductive Genetic Family, Hebei General Hospital, Shijiazhuang, P.R. ChinaSchool of Public Health, Hebei Medical University, Shijiazhuang, P.R. ChinaIt is meaningful to quantify some neurotransmitters in cerebrospinal fluid (CSF) for pathology and clinical diagnosis. The objective of this study was to develop a rapid and reliable method for detecting 5-hydroxyindole ethanol (5-HTOL), 5-hydroxyindole acetic acid (5-HIAA), 5-hydroxytryptophan (5-HTP) and 5-hydroxytryptamine (5-HT) in CSF by gas chromatography-mass spectrometry (GC-MS), and explore the clinical significance of the levels of these neurotransmitters in CSF from acute lymphoblastic leukemia (ALL).https://doi.org/10.1515/labmed-2019-01565-hydroxyindole acetic acid5-hydroxytryptaminecerebrospinal fluidgas chromatography-mass spectrometryleukemia |
| spellingShingle | Zhang Pingping Wang Bo Sun Yanmei Gao Jian Lian Kaoqi Analysis of 5-hydroxytryptamine and its related indoles in cerebrospinal fluid of leukemic children by gas chromatography-mass spectrometry Journal of Laboratory Medicine 5-hydroxyindole acetic acid 5-hydroxytryptamine cerebrospinal fluid gas chromatography-mass spectrometry leukemia |
| title | Analysis of 5-hydroxytryptamine and its related indoles in cerebrospinal fluid of leukemic children by gas chromatography-mass spectrometry |
| title_full | Analysis of 5-hydroxytryptamine and its related indoles in cerebrospinal fluid of leukemic children by gas chromatography-mass spectrometry |
| title_fullStr | Analysis of 5-hydroxytryptamine and its related indoles in cerebrospinal fluid of leukemic children by gas chromatography-mass spectrometry |
| title_full_unstemmed | Analysis of 5-hydroxytryptamine and its related indoles in cerebrospinal fluid of leukemic children by gas chromatography-mass spectrometry |
| title_short | Analysis of 5-hydroxytryptamine and its related indoles in cerebrospinal fluid of leukemic children by gas chromatography-mass spectrometry |
| title_sort | analysis of 5 hydroxytryptamine and its related indoles in cerebrospinal fluid of leukemic children by gas chromatography mass spectrometry |
| topic | 5-hydroxyindole acetic acid 5-hydroxytryptamine cerebrospinal fluid gas chromatography-mass spectrometry leukemia |
| url | https://doi.org/10.1515/labmed-2019-0156 |
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