Radiogenomic Features of GIMAP Family Genes in Clear Cell Renal Cell Carcinoma: An Observational Study on CT Images
GTPases of immunity-associated proteins (GIMAP) genes include seven functional genes and a pseudogene. Most of the GIMAPs have a role in the maintenance and development of lymphocytes. GIMAPs could inhibit the development of tumors by increasing the amount and antitumor activity of infiltrating immu...
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MDPI AG
2023-09-01
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| Series: | Genes |
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| author | Federico Greco Andrea Panunzio Alessandro Tafuri Caterina Bernetti Vincenzo Pagliarulo Bruno Beomonte Zobel Arnaldo Scardapane Carlo Augusto Mallio |
| author_facet | Federico Greco Andrea Panunzio Alessandro Tafuri Caterina Bernetti Vincenzo Pagliarulo Bruno Beomonte Zobel Arnaldo Scardapane Carlo Augusto Mallio |
| author_sort | Federico Greco |
| collection | DOAJ |
| description | GTPases of immunity-associated proteins (GIMAP) genes include seven functional genes and a pseudogene. Most of the GIMAPs have a role in the maintenance and development of lymphocytes. GIMAPs could inhibit the development of tumors by increasing the amount and antitumor activity of infiltrating immunocytes. Knowledge of key factors that affect the tumor immune microenvironment for predicting the efficacy of immunotherapy and establishing new targets in ccRCC is of great importance. A computed tomography (CT)-based radiogenomic approach was used to detect the imaging phenotypic features of GIMAP family gene expression in ccRCC. In this retrospective study we enrolled 193 ccRCC patients divided into two groups: ccRCC patients with GIMAP expression (<i>n</i> = 52) and ccRCC patients without GIMAP expression (<i>n</i> = 141). Several imaging features were evaluated on preoperative CT scan. A statistically significant correlation was found with absence of endophytic growth pattern (<i>p</i> = 0.049), tumor infiltration (<i>p</i> = 0.005), advanced age (<i>p</i> = 0.018), and high Fuhrman grade (<i>p</i> = 0.024). This study demonstrates CT imaging features of GIMAP expression in ccRCC. These results could allow the collection of data on GIMAP expression through a CT-approach and could be used for the development of a targeted therapy. |
| first_indexed | 2024-03-11T10:15:08Z |
| format | Article |
| id | doaj.art-c53cfdba948649679e5bdfea2242a058 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-11T10:15:08Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-c53cfdba948649679e5bdfea2242a0582023-11-16T10:29:28ZengMDPI AGGenes2073-44252023-09-011410183210.3390/genes14101832Radiogenomic Features of GIMAP Family Genes in Clear Cell Renal Cell Carcinoma: An Observational Study on CT ImagesFederico Greco0Andrea Panunzio1Alessandro Tafuri2Caterina Bernetti3Vincenzo Pagliarulo4Bruno Beomonte Zobel5Arnaldo Scardapane6Carlo Augusto Mallio7Department of Radiology, Cittadella Della Salute, Azienda Sanitaria Locale di Lecce, Piazza Filippo Bottazzi, 2, 73100 Lecce, ItalyDepartment of Urology, “Vito Fazzi” Hospital, Piazza Filippo Muratore, 1, 73100 Lecce, ItalyDepartment of Urology, “Vito Fazzi” Hospital, Piazza Filippo Muratore, 1, 73100 Lecce, ItalyDepartment of Medicine and Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, ItalyDepartment of Urology, “Vito Fazzi” Hospital, Piazza Filippo Muratore, 1, 73100 Lecce, ItalyDepartment of Medicine and Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, ItalyDipartimento Interdisciplinare di Medicina, Sezione di Diagnostica Per Immagini, Università degli Studi di Bari “Aldo Moro”, Piazza Giulio Cesare, 11, 70124 Bari, ItalyDepartment of Medicine and Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, ItalyGTPases of immunity-associated proteins (GIMAP) genes include seven functional genes and a pseudogene. Most of the GIMAPs have a role in the maintenance and development of lymphocytes. GIMAPs could inhibit the development of tumors by increasing the amount and antitumor activity of infiltrating immunocytes. Knowledge of key factors that affect the tumor immune microenvironment for predicting the efficacy of immunotherapy and establishing new targets in ccRCC is of great importance. A computed tomography (CT)-based radiogenomic approach was used to detect the imaging phenotypic features of GIMAP family gene expression in ccRCC. In this retrospective study we enrolled 193 ccRCC patients divided into two groups: ccRCC patients with GIMAP expression (<i>n</i> = 52) and ccRCC patients without GIMAP expression (<i>n</i> = 141). Several imaging features were evaluated on preoperative CT scan. A statistically significant correlation was found with absence of endophytic growth pattern (<i>p</i> = 0.049), tumor infiltration (<i>p</i> = 0.005), advanced age (<i>p</i> = 0.018), and high Fuhrman grade (<i>p</i> = 0.024). This study demonstrates CT imaging features of GIMAP expression in ccRCC. These results could allow the collection of data on GIMAP expression through a CT-approach and could be used for the development of a targeted therapy.https://www.mdpi.com/2073-4425/14/10/1832clear cell renal cell carcinomacomputed tomographygenesGIMAPimagingimmunocytes |
| spellingShingle | Federico Greco Andrea Panunzio Alessandro Tafuri Caterina Bernetti Vincenzo Pagliarulo Bruno Beomonte Zobel Arnaldo Scardapane Carlo Augusto Mallio Radiogenomic Features of GIMAP Family Genes in Clear Cell Renal Cell Carcinoma: An Observational Study on CT Images Genes clear cell renal cell carcinoma computed tomography genes GIMAP imaging immunocytes |
| title | Radiogenomic Features of GIMAP Family Genes in Clear Cell Renal Cell Carcinoma: An Observational Study on CT Images |
| title_full | Radiogenomic Features of GIMAP Family Genes in Clear Cell Renal Cell Carcinoma: An Observational Study on CT Images |
| title_fullStr | Radiogenomic Features of GIMAP Family Genes in Clear Cell Renal Cell Carcinoma: An Observational Study on CT Images |
| title_full_unstemmed | Radiogenomic Features of GIMAP Family Genes in Clear Cell Renal Cell Carcinoma: An Observational Study on CT Images |
| title_short | Radiogenomic Features of GIMAP Family Genes in Clear Cell Renal Cell Carcinoma: An Observational Study on CT Images |
| title_sort | radiogenomic features of gimap family genes in clear cell renal cell carcinoma an observational study on ct images |
| topic | clear cell renal cell carcinoma computed tomography genes GIMAP imaging immunocytes |
| url | https://www.mdpi.com/2073-4425/14/10/1832 |
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