Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation
Cellular metabolism is important in pluripotency and cell fate regulation. Here, authors observe chromatin remodeling followed by TCA enzyme translocation from the mitochondria to the nucleus, demonstrating pluripotency regulation by mitochondria to nucleus retrograde signaling.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35199-0 |
| _version_ | 1811207689169010688 |
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| author | Wei Li Qi Long Hao Wu Yanshuang Zhou Lifan Duan Hao Yuan Yingzhe Ding Yile Huang Yi Wu Jinyu Huang Delong Liu Baodan Chen Jian Zhang Juntao Qi Shiwei Du Linpeng Li Yang Liu Zifeng Ruan Zihuang Liu Zichao Liu Yifan Zhao Jianghuan Lu Junwei Wang Wai-Yee Chan Xingguo Liu |
| author_facet | Wei Li Qi Long Hao Wu Yanshuang Zhou Lifan Duan Hao Yuan Yingzhe Ding Yile Huang Yi Wu Jinyu Huang Delong Liu Baodan Chen Jian Zhang Juntao Qi Shiwei Du Linpeng Li Yang Liu Zifeng Ruan Zihuang Liu Zichao Liu Yifan Zhao Jianghuan Lu Junwei Wang Wai-Yee Chan Xingguo Liu |
| author_sort | Wei Li |
| collection | DOAJ |
| description | Cellular metabolism is important in pluripotency and cell fate regulation. Here, authors observe chromatin remodeling followed by TCA enzyme translocation from the mitochondria to the nucleus, demonstrating pluripotency regulation by mitochondria to nucleus retrograde signaling. |
| first_indexed | 2024-04-12T04:07:49Z |
| format | Article |
| id | doaj.art-c53d76e31af847fdb1f261bf98cc7868 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T04:07:49Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c53d76e31af847fdb1f261bf98cc78682022-12-22T03:48:34ZengNature PortfolioNature Communications2041-17232022-12-0113111510.1038/s41467-022-35199-0Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylationWei Li0Qi Long1Hao Wu2Yanshuang Zhou3Lifan Duan4Hao Yuan5Yingzhe Ding6Yile Huang7Yi Wu8Jinyu Huang9Delong Liu10Baodan Chen11Jian Zhang12Juntao Qi13Shiwei Du14Linpeng Li15Yang Liu16Zifeng Ruan17Zihuang Liu18Zichao Liu19Yifan Zhao20Jianghuan Lu21Junwei Wang22Wai-Yee Chan23Xingguo Liu24GMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityGMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityGMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityGMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityGMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityGMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityCentre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of SciencesCentre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of SciencesGMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityGMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityGMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityGMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityGMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityGMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityGMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityGMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityGMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityGMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityGMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityGMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityGuangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, China-New Zealand Joint Laboratory on Biomedicine and Health, CUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative Medicine, Institute for Stem Cell and Regeneration, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesGMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityGMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityCUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative Medicine, Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong KongGMU-GIBH Joint School of Life Sciences, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; Guangzhou Medical UniversityCellular metabolism is important in pluripotency and cell fate regulation. Here, authors observe chromatin remodeling followed by TCA enzyme translocation from the mitochondria to the nucleus, demonstrating pluripotency regulation by mitochondria to nucleus retrograde signaling.https://doi.org/10.1038/s41467-022-35199-0 |
| spellingShingle | Wei Li Qi Long Hao Wu Yanshuang Zhou Lifan Duan Hao Yuan Yingzhe Ding Yile Huang Yi Wu Jinyu Huang Delong Liu Baodan Chen Jian Zhang Juntao Qi Shiwei Du Linpeng Li Yang Liu Zifeng Ruan Zihuang Liu Zichao Liu Yifan Zhao Jianghuan Lu Junwei Wang Wai-Yee Chan Xingguo Liu Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation Nature Communications |
| title | Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation |
| title_full | Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation |
| title_fullStr | Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation |
| title_full_unstemmed | Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation |
| title_short | Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation |
| title_sort | nuclear localization of mitochondrial tca cycle enzymes modulates pluripotency via histone acetylation |
| url | https://doi.org/10.1038/s41467-022-35199-0 |
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