Construction of a synthetic methodology-based library and its application in identifying a GIT/PIX protein–protein interaction inhibitor
Chemical libraries with skeleton diversity are important for drug discovery. Here, the authors establish a synthetic methodology-based compound library (SMBL), and apply it to identify a small-molecule inhibitor to interrupt a challenging target: the protein–protein interaction (PPI) of GIT1/β-Pix....
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Bibliographic Details
| Main Authors: |
Jing Gu,
Rui-Kun Peng,
Chun-Ling Guo,
Meng Zhang,
Jie Yang,
Xiao Yan,
Qian Zhou,
Hongwei Li,
Na Wang,
Jinwei Zhu,
Qin Ouyang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-34598-7
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