Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms
J Carlos Villa Guzmán,1 J Espinosa,1 R Cervera,1 M Delgado,2 R Patón,3 JM Cordero García41Department of Medical Oncology, 2Department of Pathology, 3Department of Gastroenterology, 4Department of Nuclear Medicine, University Ciudad Real General Hospital, Ciudad Real,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-12-01
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| Series: | Breast Cancer: Targets and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/gastric-and-colon-metastasis-from-breast-cancer-case-report-review-of--peer-reviewed-article-BCTT |
| _version_ | 1818427822056669184 |
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| author | Villa Guzmán JC Espinosa J Cervera R Delgado M Patón R Cordero García JM |
| author_facet | Villa Guzmán JC Espinosa J Cervera R Delgado M Patón R Cordero García JM |
| author_sort | Villa Guzmán JC |
| collection | DOAJ |
| description | J Carlos Villa Guzmán,1 J Espinosa,1 R Cervera,1 M Delgado,2 R Patón,3 JM Cordero García41Department of Medical Oncology, 2Department of Pathology, 3Department of Gastroenterology, 4Department of Nuclear Medicine, University Ciudad Real General Hospital, Ciudad Real, Spain Abstract: Gastrointestinal metastases from breast cancer are not common. We present a 58-year-old female diagnosed with lobular breast cancer some years before whose relapses were gastric and colonic mucosal. Simultaneous metastases are extremely rare. To our knowledge, no cases of initial dual affectation have been reported. The patient also showed gastritis by Helicobacter pylori. Invasive lobular breast carcinoma is the most frequent special type of breast cancer and carries some specific molecular alterations such as loss of expression of E-cadherin. Although underlying mechanisms of metastasization are not entirely known, chemokines as well as inflammatory events seem to be implicated in this process. Interaction between chemokines and their receptors frequently induces cell migration. We hypothesize that H. pylori, inflammatory cells, and chemokines may create a favorable environment attracting tumor cells. Keywords: chemokines, gastrointestinal metastases, H. pylori, lobular carcinoma |
| first_indexed | 2024-12-14T14:51:50Z |
| format | Article |
| id | doaj.art-c53f76a987744862bd40643926242e1f |
| institution | Directory Open Access Journal |
| issn | 1179-1314 |
| language | English |
| last_indexed | 2024-12-14T14:51:50Z |
| publishDate | 2016-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Breast Cancer: Targets and Therapy |
| spelling | doaj.art-c53f76a987744862bd40643926242e1f2022-12-21T22:57:07ZengDove Medical PressBreast Cancer: Targets and Therapy1179-13142016-12-01Volume 91730662Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanismsVilla Guzmán JCEspinosa JCervera RDelgado MPatón RCordero García JMJ Carlos Villa Guzmán,1 J Espinosa,1 R Cervera,1 M Delgado,2 R Patón,3 JM Cordero García41Department of Medical Oncology, 2Department of Pathology, 3Department of Gastroenterology, 4Department of Nuclear Medicine, University Ciudad Real General Hospital, Ciudad Real, Spain Abstract: Gastrointestinal metastases from breast cancer are not common. We present a 58-year-old female diagnosed with lobular breast cancer some years before whose relapses were gastric and colonic mucosal. Simultaneous metastases are extremely rare. To our knowledge, no cases of initial dual affectation have been reported. The patient also showed gastritis by Helicobacter pylori. Invasive lobular breast carcinoma is the most frequent special type of breast cancer and carries some specific molecular alterations such as loss of expression of E-cadherin. Although underlying mechanisms of metastasization are not entirely known, chemokines as well as inflammatory events seem to be implicated in this process. Interaction between chemokines and their receptors frequently induces cell migration. We hypothesize that H. pylori, inflammatory cells, and chemokines may create a favorable environment attracting tumor cells. Keywords: chemokines, gastrointestinal metastases, H. pylori, lobular carcinomahttps://www.dovepress.com/gastric-and-colon-metastasis-from-breast-cancer-case-report-review-of--peer-reviewed-article-BCTTLobular breast cancergastrointestinal metastases and chemokines |
| spellingShingle | Villa Guzmán JC Espinosa J Cervera R Delgado M Patón R Cordero García JM Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms Breast Cancer: Targets and Therapy Lobular breast cancer gastrointestinal metastases and chemokines |
| title | Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms |
| title_full | Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms |
| title_fullStr | Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms |
| title_full_unstemmed | Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms |
| title_short | Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms |
| title_sort | gastric and colon metastasis from breast cancer case report review of the literature and possible underlying mechanisms |
| topic | Lobular breast cancer gastrointestinal metastases and chemokines |
| url | https://www.dovepress.com/gastric-and-colon-metastasis-from-breast-cancer-case-report-review-of--peer-reviewed-article-BCTT |
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