Cytokines and Inflammatory Mediators in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by a breakdown in immune tolerance that induces an attack on normal tissues by the immune system. The dysfunction within both the innate and adaptive immune systems increases cytokine production, B lymphocytic overproduction o...
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| Format: | Article |
| Language: | English |
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European Medical Journal
2018-07-01
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| Series: | European Medical Journal Rheumatology |
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| Online Access: | https://www.emjreviews.com/rheumatology/article/cytokines-and-inflammatory-mediators-in-systemic-lupus-erythematosus/ |
| _version_ | 1819036152150097920 |
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| author | Manuel Rojas Yhojan Rodríguez Kelly Joan Leon Yovana Pacheco Yeny Acosta-Ampudia Diana M. Monsalve Carolina Ramírez-Santana Juan-Manuel Anaya |
| author_facet | Manuel Rojas Yhojan Rodríguez Kelly Joan Leon Yovana Pacheco Yeny Acosta-Ampudia Diana M. Monsalve Carolina Ramírez-Santana Juan-Manuel Anaya |
| author_sort | Manuel Rojas |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by a breakdown in immune tolerance that induces an attack on normal tissues by the immune system. The dysfunction within both the innate and adaptive immune systems increases cytokine production, B lymphocytic overproduction of autoantibodies, and T lymphocyte activity. Cytokines and inflammatory mediators have been associated with several clinical endpoints, including the activity of disease and outcomes. In fact, some of them have been associated with different clinical subphenotypes (e.g., lupus nephritis), suggesting their role as biomarkers, and, in some cases, therapeutic targets. Thus, knowledge of the pathophysiological processes associated with the development of SLE could aid in setting up better diagnostic and therapeutic approaches to reduce the high burden of disease, and thus improve quality of life and outcomes. Herein, the authors have compiled a concise review of the clinically relevant cytokines and inflammatory mediators associated with SLE and its manifestations. |
| first_indexed | 2024-12-21T08:00:58Z |
| format | Article |
| id | doaj.art-c53ff35a46084a2d8d9e65725f6a374e |
| institution | Directory Open Access Journal |
| issn | 2056-6395 |
| language | English |
| last_indexed | 2024-12-21T08:00:58Z |
| publishDate | 2018-07-01 |
| publisher | European Medical Journal |
| record_format | Article |
| series | European Medical Journal Rheumatology |
| spelling | doaj.art-c53ff35a46084a2d8d9e65725f6a374e2022-12-21T19:10:54ZengEuropean Medical JournalEuropean Medical Journal Rheumatology2056-63952018-07-01518392Cytokines and Inflammatory Mediators in Systemic Lupus ErythematosusManuel Rojas0Yhojan Rodríguez1Kelly Joan Leon2Yovana Pacheco3Yeny Acosta-Ampudia4Diana M. Monsalve5Carolina Ramírez-Santana6Juan-Manuel Anaya7Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, ColombiaCenter for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, ColombiaCenter for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, ColombiaCenter for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, ColombiaCenter for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, ColombiaCenter for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, ColombiaCenter for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, ColombiaCenter for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, ColombiaSystemic lupus erythematosus (SLE) is an autoimmune disease characterised by a breakdown in immune tolerance that induces an attack on normal tissues by the immune system. The dysfunction within both the innate and adaptive immune systems increases cytokine production, B lymphocytic overproduction of autoantibodies, and T lymphocyte activity. Cytokines and inflammatory mediators have been associated with several clinical endpoints, including the activity of disease and outcomes. In fact, some of them have been associated with different clinical subphenotypes (e.g., lupus nephritis), suggesting their role as biomarkers, and, in some cases, therapeutic targets. Thus, knowledge of the pathophysiological processes associated with the development of SLE could aid in setting up better diagnostic and therapeutic approaches to reduce the high burden of disease, and thus improve quality of life and outcomes. Herein, the authors have compiled a concise review of the clinically relevant cytokines and inflammatory mediators associated with SLE and its manifestations.https://www.emjreviews.com/rheumatology/article/cytokines-and-inflammatory-mediators-in-systemic-lupus-erythematosus/Biomarkerscytokinesinflammationinflammatory mediatorssystemic lupus erythematosus (SLE) |
| spellingShingle | Manuel Rojas Yhojan Rodríguez Kelly Joan Leon Yovana Pacheco Yeny Acosta-Ampudia Diana M. Monsalve Carolina Ramírez-Santana Juan-Manuel Anaya Cytokines and Inflammatory Mediators in Systemic Lupus Erythematosus European Medical Journal Rheumatology Biomarkers cytokines inflammation inflammatory mediators systemic lupus erythematosus (SLE) |
| title | Cytokines and Inflammatory Mediators in Systemic Lupus Erythematosus |
| title_full | Cytokines and Inflammatory Mediators in Systemic Lupus Erythematosus |
| title_fullStr | Cytokines and Inflammatory Mediators in Systemic Lupus Erythematosus |
| title_full_unstemmed | Cytokines and Inflammatory Mediators in Systemic Lupus Erythematosus |
| title_short | Cytokines and Inflammatory Mediators in Systemic Lupus Erythematosus |
| title_sort | cytokines and inflammatory mediators in systemic lupus erythematosus |
| topic | Biomarkers cytokines inflammation inflammatory mediators systemic lupus erythematosus (SLE) |
| url | https://www.emjreviews.com/rheumatology/article/cytokines-and-inflammatory-mediators-in-systemic-lupus-erythematosus/ |
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