Прогностическая значимость умеренных когнитивных нарушений у пациентов с высоким и очень высоким кардиоваскулярным риском
Aim. To assess the prognostic significance of cognitive impairments detected using the MMSE scale in patients at high and very high cardiovascular risk (CVR).Patients and methods. The study included men and women aged 40-75 years at high and very high CVR, determined in accordance with the recommend...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2020-09-01
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| Series: | Неврология, нейропсихиатрия, психосоматика |
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| Online Access: | https://nnp.ima-press.net/nnp/article/view/1189 |
| _version_ | 1797758661084315648 |
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| author | В. В. Генкель А. С. Кузнецова А. О. Салашенко Е. В. Лебедев И. И. Шапошник |
| author_facet | В. В. Генкель А. С. Кузнецова А. О. Салашенко Е. В. Лебедев И. И. Шапошник |
| author_sort | В. В. Генкель |
| collection | DOAJ |
| description | Aim. To assess the prognostic significance of cognitive impairments detected using the MMSE scale in patients at high and very high cardiovascular risk (CVR).Patients and methods. The study included men and women aged 40-75 years at high and very high CVR, determined in accordance with the recommendations of the European Society of Cardiology on cardiovascular prevention in 2016. The study included 111 patients at high and very high CVR. High CVR was established in 30 (27,0%) patients. Very high CVR was established in 81 (73,0%) patients. The median MMSE score in the studied group of patients was 28,0 (27,0-28,0). 71 (63,9%) patients scored ≥28 points on the MMSE scale. Mild cognitive impairment (MCI) were detected in 40 (36,1%) people. Among the examined patients there were no patients with dementia. The duration of the observation period was 24,6 (14,4-34,5) months. The combined end point was cardiovascular death, nonfatal myocardial infarction or unstable angina, requiring hospitalization, nonfatal stroke, coronary revascularization.Results. Events constituting the combined endpoint occurred in 40 (36,0%) patients. According to the results of the Kaplan-Meier analysis, patients with MCI differed significantly lower survival over the observation period of more than 2 years. According to the Cox regression data, MCI was associated with an increase in the relative risk of adverse cardiovascular events constituting the end point, by 2,56 times (95% CI 1,22-5,33; p = 0,013).Conclusion. The presence of mild cognitive impairment was associated with an increase in the relative risk of adverse cardiovascular events. |
| first_indexed | 2024-03-12T18:33:17Z |
| format | Article |
| id | doaj.art-c540a138e7574c98a8e38ccf1c5b527e |
| institution | Directory Open Access Journal |
| issn | 2074-2711 2310-1342 |
| language | Russian |
| last_indexed | 2024-03-12T18:33:17Z |
| publishDate | 2020-09-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Неврология, нейропсихиатрия, психосоматика |
| spelling | doaj.art-c540a138e7574c98a8e38ccf1c5b527e2023-08-02T08:11:21ZrusIMA-PRESS LLCНеврология, нейропсихиатрия, психосоматика2074-27112310-13422020-09-0100906Прогностическая значимость умеренных когнитивных нарушений у пациентов с высоким и очень высоким кардиоваскулярным рискомВ. В. Генкель0А. С. Кузнецова1А. О. Салашенко2Е. В. Лебедев3И. И. Шапошник4ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава РоссииФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава РоссииAim. To assess the prognostic significance of cognitive impairments detected using the MMSE scale in patients at high and very high cardiovascular risk (CVR).Patients and methods. The study included men and women aged 40-75 years at high and very high CVR, determined in accordance with the recommendations of the European Society of Cardiology on cardiovascular prevention in 2016. The study included 111 patients at high and very high CVR. High CVR was established in 30 (27,0%) patients. Very high CVR was established in 81 (73,0%) patients. The median MMSE score in the studied group of patients was 28,0 (27,0-28,0). 71 (63,9%) patients scored ≥28 points on the MMSE scale. Mild cognitive impairment (MCI) were detected in 40 (36,1%) people. Among the examined patients there were no patients with dementia. The duration of the observation period was 24,6 (14,4-34,5) months. The combined end point was cardiovascular death, nonfatal myocardial infarction or unstable angina, requiring hospitalization, nonfatal stroke, coronary revascularization.Results. Events constituting the combined endpoint occurred in 40 (36,0%) patients. According to the results of the Kaplan-Meier analysis, patients with MCI differed significantly lower survival over the observation period of more than 2 years. According to the Cox regression data, MCI was associated with an increase in the relative risk of adverse cardiovascular events constituting the end point, by 2,56 times (95% CI 1,22-5,33; p = 0,013).Conclusion. The presence of mild cognitive impairment was associated with an increase in the relative risk of adverse cardiovascular events.https://nnp.ima-press.net/nnp/article/view/1189mild cognitive impairmentcardiovascular riskmmsesurvival |
| spellingShingle | В. В. Генкель А. С. Кузнецова А. О. Салашенко Е. В. Лебедев И. И. Шапошник Прогностическая значимость умеренных когнитивных нарушений у пациентов с высоким и очень высоким кардиоваскулярным риском Неврология, нейропсихиатрия, психосоматика mild cognitive impairment cardiovascular risk mmse survival |
| title | Прогностическая значимость умеренных когнитивных нарушений у пациентов с высоким и очень высоким кардиоваскулярным риском |
| title_full | Прогностическая значимость умеренных когнитивных нарушений у пациентов с высоким и очень высоким кардиоваскулярным риском |
| title_fullStr | Прогностическая значимость умеренных когнитивных нарушений у пациентов с высоким и очень высоким кардиоваскулярным риском |
| title_full_unstemmed | Прогностическая значимость умеренных когнитивных нарушений у пациентов с высоким и очень высоким кардиоваскулярным риском |
| title_short | Прогностическая значимость умеренных когнитивных нарушений у пациентов с высоким и очень высоким кардиоваскулярным риском |
| title_sort | прогностическая значимость умеренных когнитивных нарушений у пациентов с высоким и очень высоким кардиоваскулярным риском |
| topic | mild cognitive impairment cardiovascular risk mmse survival |
| url | https://nnp.ima-press.net/nnp/article/view/1189 |
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