New bioactive triaryl triglyceride esters: Synthesis, characterization and biological activities
Four new bioactive aryl triester derivatives of glycerol and benzoic acids were synthesized. The synthetic compounds were studied for their antimicrobial and urease inhibition activities. Esterification was carried out by using carbonyldiimidazole to enhance the acyl elimination addition reaction wi...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bangladesh Pharmacological Society
2018-10-01
|
| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/37210 |
| _version_ | 1818269893971148800 |
|---|---|
| author | Tanzila Arshad Hamdullah Khadim Sheikh Mehdi Hassan Kazmi Sadia Farheen Tehmina Sohail Mehreen Lateef |
| author_facet | Tanzila Arshad Hamdullah Khadim Sheikh Mehdi Hassan Kazmi Sadia Farheen Tehmina Sohail Mehreen Lateef |
| author_sort | Tanzila Arshad |
| collection | DOAJ |
| description | Four new bioactive aryl triester derivatives of glycerol and benzoic acids were synthesized. The synthetic compounds were studied for their antimicrobial and urease inhibition activities. Esterification was carried out by using carbonyldiimidazole to enhance the acyl elimination addition reaction with benzoic acid derivatives. The structure of triglycerides were studied by EI-MS, 1H, 13C-NMR, FT-IR and elemental analysis. All synthetic compounds showed urease inhibition activity with highest value of IC50 value 22.4 ± 0.45 μM which is nearest to standard thiourea IC50 value (21.6 ± 0.12 μM). Except compound (3d), all other compounds exhibited antimicrobial activity against Streptococcus pneumoniae, Staphylococcus epidermidis, Bacillus pumilus, Escherichia coli, Pseudomonas aeruginosa and Candida albican.
Video Clip of Methodology:
7 min 59 sec Full Screen Alternate |
| first_indexed | 2024-12-12T21:01:38Z |
| format | Article |
| id | doaj.art-c5417dafe0454aed9d07cbf1bc98b677 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-12T21:01:38Z |
| publishDate | 2018-10-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-c5417dafe0454aed9d07cbf1bc98b6772022-12-22T00:12:08ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882018-10-0113410.3329/bjp.v13i4.37210New bioactive triaryl triglyceride esters: Synthesis, characterization and biological activitiesTanzila Arshad0Hamdullah Khadim Sheikh1Mehdi Hassan Kazmi2Sadia Farheen3Tehmina Sohail4Mehreen Lateef5Department of Applied Chemistry, University of Karachi, Karachi 75270, Pakistan.Department of Applied Chemistry, University of Karachi, Karachi 75270, Pakistan.Department of Applied Chemistry, University of Karachi, Karachi 75270, Pakistan.Pakistan Council of Scientific and Industrial Research Laboratories Complex, Karachi, Pakistan.Pakistan Council of Scientific and Industrial Research Laboratories Complex, Karachi, Pakistan.Bahria University Medical and Dental College, Karachi, Pakistan.Four new bioactive aryl triester derivatives of glycerol and benzoic acids were synthesized. The synthetic compounds were studied for their antimicrobial and urease inhibition activities. Esterification was carried out by using carbonyldiimidazole to enhance the acyl elimination addition reaction with benzoic acid derivatives. The structure of triglycerides were studied by EI-MS, 1H, 13C-NMR, FT-IR and elemental analysis. All synthetic compounds showed urease inhibition activity with highest value of IC50 value 22.4 ± 0.45 μM which is nearest to standard thiourea IC50 value (21.6 ± 0.12 μM). Except compound (3d), all other compounds exhibited antimicrobial activity against Streptococcus pneumoniae, Staphylococcus epidermidis, Bacillus pumilus, Escherichia coli, Pseudomonas aeruginosa and Candida albican. Video Clip of Methodology: 7 min 59 sec Full Screen Alternatehttps://www.banglajol.info/index.php/BJP/article/view/37210AntimicrobialGlycerolSynthesisTriglyceridesUrease inhibition |
| spellingShingle | Tanzila Arshad Hamdullah Khadim Sheikh Mehdi Hassan Kazmi Sadia Farheen Tehmina Sohail Mehreen Lateef New bioactive triaryl triglyceride esters: Synthesis, characterization and biological activities Bangladesh Journal of Pharmacology Antimicrobial Glycerol Synthesis Triglycerides Urease inhibition |
| title | New bioactive triaryl triglyceride esters: Synthesis, characterization and biological activities |
| title_full | New bioactive triaryl triglyceride esters: Synthesis, characterization and biological activities |
| title_fullStr | New bioactive triaryl triglyceride esters: Synthesis, characterization and biological activities |
| title_full_unstemmed | New bioactive triaryl triglyceride esters: Synthesis, characterization and biological activities |
| title_short | New bioactive triaryl triglyceride esters: Synthesis, characterization and biological activities |
| title_sort | new bioactive triaryl triglyceride esters synthesis characterization and biological activities |
| topic | Antimicrobial Glycerol Synthesis Triglycerides Urease inhibition |
| url | https://www.banglajol.info/index.php/BJP/article/view/37210 |
| work_keys_str_mv | AT tanzilaarshad newbioactivetriaryltriglycerideesterssynthesischaracterizationandbiologicalactivities AT hamdullahkhadimsheikh newbioactivetriaryltriglycerideesterssynthesischaracterizationandbiologicalactivities AT mehdihassankazmi newbioactivetriaryltriglycerideesterssynthesischaracterizationandbiologicalactivities AT sadiafarheen newbioactivetriaryltriglycerideesterssynthesischaracterizationandbiologicalactivities AT tehminasohail newbioactivetriaryltriglycerideesterssynthesischaracterizationandbiologicalactivities AT mehreenlateef newbioactivetriaryltriglycerideesterssynthesischaracterizationandbiologicalactivities |