A novel dual MEK/PDK1 inhibitor 9za retards the cell cycle at G0/G1 phase and induces mitochondrial apoptosis in non-small cell lung cancer cells

A novel dual MEK/PDK1 inhibitor 9za retards the cell cycle at G0/G1 phase and induces mitochondrial apoptosis in non-small cell lung cancer cells

Background A novel dual MEK/PDK1 inhibitor named 9za has been synthesized by our research team. Preliminary study showed that 9za possessed potent cytotoxicity and proapoptosis in non-small cell lung cancer (NSCLC) cells. Nevertheless, the precise underlying mechanism is vague. Methods In this work,...

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Bibliographic Details
Main Authors: Rangru Liu, Zutao Yu, Zhuo Chen, Danqi Liu, Fengying Huang, Qianbin Li, Gaoyun Hu, Xinan Yi, Xi Li, Honghao Zhou, Zhaoqian Liu
Format: Article
Language:English
Published: PeerJ Inc. 2020-10-01
Series:PeerJ
Subjects:
A dual MEK/PDK1 inhibitor
9za
Cytotoxicity
Cell cycle arrest
Mitochondrial apoptosis
Non-small cell lung cancer
Online Access:https://peerj.com/articles/9981.pdf

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