Antioxidant vitamin status of obese patients in terms of the risk of comorbidities
BACKGROUND: Synchronously optimized concentrations of vitamins C, E, A, carotenoids and their ratios in blood plasma help to prevent or slow down the development of many alimentary-dependent diseases and their complications. AIMS: to characterize the vitamin status of obese patients from the standpo...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Endocrinology Research Centre
2020-06-01
|
| Series: | Ожирение и метаболизм |
| Subjects: | |
| Online Access: | https://www.omet-endojournals.ru/jour/article/view/10144 |
| _version_ | 1797204628995047424 |
|---|---|
| author | Vera M. Kodentsova Oksana A. Vrzhesinskaya Olga V. Kosheleva Nina А. Beketova Khaider Kh. Sharafetdinov |
| author_facet | Vera M. Kodentsova Oksana A. Vrzhesinskaya Olga V. Kosheleva Nina А. Beketova Khaider Kh. Sharafetdinov |
| author_sort | Vera M. Kodentsova |
| collection | DOAJ |
| description | BACKGROUND: Synchronously optimized concentrations of vitamins C, E, A, carotenoids and their ratios in blood plasma help to prevent or slow down the development of many alimentary-dependent diseases and their complications. AIMS: to characterize the vitamin status of obese patients from the standpoint of the risk of progression of existing and development of associated diseases. MATERIALS AND METHODS: An observational single-site cross-sectional study of the sufficiency with antioxidant vitamins in 81 patients (21 men, 60 women) aged 20–75 years with body mass index 40,7±1,2 kg/m2, enrolled for treatment from April to June in Federal Research Centre of Nutrition, Biotechnology had been conducted. The concentration of α- and γ-tocopherols, retinol, ascorbic acid, β-carotene was determined in blood serum and their ratios with lipid profile were calculated. RESULTS: Indicators of vitamin status were determined in 35 patients with obesity, 27 patients with obesity and cardiovascular diseases (CVD), 19 patients with obesity and type 2 diabetes mellitus (T2DM). The concentration of ascorbic acid in more than 50% of patients did not reach the optimal level (50 µmol/l). Compared to patients of other groups, patients with T2DM were better supplied with vitamin E, but worse with other vitamins. They have a non-optimal ratio of concentrations of vitamin C and E more often compared with patients of other groups (p≤0.050). Among them, the combined suboptimal level of vitamin C and β-carotene (<0.4 µmol/l) was detected 1.6–1.8 fold more often. The lack of antioxidants in patients with T2DM according to simultaneously reduced vitamin C/vitamin E ratio (<1.5) and β-carotene level was detected 3.3-fold more often, synchronously lowered vitamin C/vitamin E ratio and vitamin C level – 2.4-fold. γ-tocopherol level in serum of patients with T2DM tended to increase compared with that in patients with obesity (p=0.063) and CVD (p=0.081), γ-tocopherol/triacylglycerides ratio was 1.5-fold higher (respectively р=0.009 и р=0.076). Only in 2 patients with obesity and 2 patients with CVD all serum indicators corresponded to the optimal level of all vitamins. In terms of α-tocopherol/cholesterol (<5 µmol/mol), an increased risk of myocardial infarction was detected in 10.5–42.9% of the examined patients. Glucose level was positively associated with serum levels of α- and γ-tocopherols, as well as cholesterol-adjusted individual tocopherols; while glycemia was inversely associated with triacylglycerides-standardized individual tocopherols, as well as β-carotene and vitamin C/vitamin E ratio. CONCLUSIONS: In most patients, a non-optimal serum vitamin content was found according to one or several parameters. In order to vitamin C/vitamin E ratio, patients with T2DM need to increase vitamin C intake. Increasing serum β-carotene and achieving an optimal C/E ratio will help to prevent an increase in glycemia. |
| first_indexed | 2024-03-08T09:13:37Z |
| format | Article |
| id | doaj.art-c54411e8ecb94a1683e059a5ec6cd186 |
| institution | Directory Open Access Journal |
| issn | 2071-8713 2306-5524 |
| language | English |
| last_indexed | 2024-04-24T08:38:15Z |
| publishDate | 2020-06-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Ожирение и метаболизм |
| spelling | doaj.art-c54411e8ecb94a1683e059a5ec6cd1862024-04-16T16:16:12ZengEndocrinology Research CentreОжирение и метаболизм2071-87132306-55242020-06-01171223210.14341/omet1014410625Antioxidant vitamin status of obese patients in terms of the risk of comorbiditiesVera M. Kodentsova0Oksana A. Vrzhesinskaya1Olga V. Kosheleva2Nina А. Beketova3Khaider Kh. Sharafetdinov4Federal Research Centre of Nutrition, Biotechnology and Food SafetyFederal Research Centre of Nutrition, Biotechnology and Food SafetyFederal Research Centre of Nutrition, Biotechnology and Food SafetyFederal Research Centre of Nutrition, Biotechnology and Food SafetyFederal Research Centre of Nutrition, Biotechnology and Food Safety; Russian Medical Academy of Post-Graduate Education; I.M. Sechenov First Moscow State Medical UniversityBACKGROUND: Synchronously optimized concentrations of vitamins C, E, A, carotenoids and their ratios in blood plasma help to prevent or slow down the development of many alimentary-dependent diseases and their complications. AIMS: to characterize the vitamin status of obese patients from the standpoint of the risk of progression of existing and development of associated diseases. MATERIALS AND METHODS: An observational single-site cross-sectional study of the sufficiency with antioxidant vitamins in 81 patients (21 men, 60 women) aged 20–75 years with body mass index 40,7±1,2 kg/m2, enrolled for treatment from April to June in Federal Research Centre of Nutrition, Biotechnology had been conducted. The concentration of α- and γ-tocopherols, retinol, ascorbic acid, β-carotene was determined in blood serum and their ratios with lipid profile were calculated. RESULTS: Indicators of vitamin status were determined in 35 patients with obesity, 27 patients with obesity and cardiovascular diseases (CVD), 19 patients with obesity and type 2 diabetes mellitus (T2DM). The concentration of ascorbic acid in more than 50% of patients did not reach the optimal level (50 µmol/l). Compared to patients of other groups, patients with T2DM were better supplied with vitamin E, but worse with other vitamins. They have a non-optimal ratio of concentrations of vitamin C and E more often compared with patients of other groups (p≤0.050). Among them, the combined suboptimal level of vitamin C and β-carotene (<0.4 µmol/l) was detected 1.6–1.8 fold more often. The lack of antioxidants in patients with T2DM according to simultaneously reduced vitamin C/vitamin E ratio (<1.5) and β-carotene level was detected 3.3-fold more often, synchronously lowered vitamin C/vitamin E ratio and vitamin C level – 2.4-fold. γ-tocopherol level in serum of patients with T2DM tended to increase compared with that in patients with obesity (p=0.063) and CVD (p=0.081), γ-tocopherol/triacylglycerides ratio was 1.5-fold higher (respectively р=0.009 и р=0.076). Only in 2 patients with obesity and 2 patients with CVD all serum indicators corresponded to the optimal level of all vitamins. In terms of α-tocopherol/cholesterol (<5 µmol/mol), an increased risk of myocardial infarction was detected in 10.5–42.9% of the examined patients. Glucose level was positively associated with serum levels of α- and γ-tocopherols, as well as cholesterol-adjusted individual tocopherols; while glycemia was inversely associated with triacylglycerides-standardized individual tocopherols, as well as β-carotene and vitamin C/vitamin E ratio. CONCLUSIONS: In most patients, a non-optimal serum vitamin content was found according to one or several parameters. In order to vitamin C/vitamin E ratio, patients with T2DM need to increase vitamin C intake. Increasing serum β-carotene and achieving an optimal C/E ratio will help to prevent an increase in glycemia.https://www.omet-endojournals.ru/jour/article/view/10144antioxidantsvitaminssuboptimal concentrationserumcholesterol-adjusted α-tocopheroltriacylglyceridesobesity |
| spellingShingle | Vera M. Kodentsova Oksana A. Vrzhesinskaya Olga V. Kosheleva Nina А. Beketova Khaider Kh. Sharafetdinov Antioxidant vitamin status of obese patients in terms of the risk of comorbidities Ожирение и метаболизм antioxidants vitamins suboptimal concentration serum cholesterol-adjusted α-tocopherol triacylglycerides obesity |
| title | Antioxidant vitamin status of obese patients in terms of the risk of comorbidities |
| title_full | Antioxidant vitamin status of obese patients in terms of the risk of comorbidities |
| title_fullStr | Antioxidant vitamin status of obese patients in terms of the risk of comorbidities |
| title_full_unstemmed | Antioxidant vitamin status of obese patients in terms of the risk of comorbidities |
| title_short | Antioxidant vitamin status of obese patients in terms of the risk of comorbidities |
| title_sort | antioxidant vitamin status of obese patients in terms of the risk of comorbidities |
| topic | antioxidants vitamins suboptimal concentration serum cholesterol-adjusted α-tocopherol triacylglycerides obesity |
| url | https://www.omet-endojournals.ru/jour/article/view/10144 |
| work_keys_str_mv | AT veramkodentsova antioxidantvitaminstatusofobesepatientsintermsoftheriskofcomorbidities AT oksanaavrzhesinskaya antioxidantvitaminstatusofobesepatientsintermsoftheriskofcomorbidities AT olgavkosheleva antioxidantvitaminstatusofobesepatientsintermsoftheriskofcomorbidities AT ninaabeketova antioxidantvitaminstatusofobesepatientsintermsoftheriskofcomorbidities AT khaiderkhsharafetdinov antioxidantvitaminstatusofobesepatientsintermsoftheriskofcomorbidities |